Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers

Hanne H Villesen; Kim Kristensen; Steen H Hansen; Niels-Henrik Jensen; Ulrik Skram; Lona Louring Christrup

doi:10.1007/s00228-007-0306-4

Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers

Hanne H Villesen, Kim Kristensen, Steen H Hansen, Niels-Henrik Jensen, Ulrik Skram, Lona Louring Christrup

10 Citations (Scopus)

Abstract

After oral administration, morphine-6-glucuronide (M6G) displays an atypical absorption profile with two peak plasma concentrations. A proposed explanation is that M6G is hydrolysed to morphine in the colon, which is then absorbed and subsequently undergoes metabolism in the liver to morphine-3-glucuronide (M3G) and M6G. The aims of this study were to confirm and elucidate the biphasic absorption profile as well as clarify the conversion of M6G to morphine after a single oral administration of M6G in healthy volunteers.

Original language	English
Journal	European Journal of Clinical Pharmacology
Volume	63
Issue number	8
Pages (from-to)	761-7
Number of pages	7
ISSN	0031-6970
DOIs	https://doi.org/10.1007/s00228-007-0306-4
Publication status	Published - 1 Aug 2007

Keywords

Absorption
Administration, Oral
Adolescent
Adult
Analgesics, Opioid
Cross-Over Studies
Humans
Hydrolysis
Male
Morphine
Morphine Derivatives

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10.1007/s00228-007-0306-4

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title = "Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers",

abstract = "After oral administration, morphine-6-glucuronide (M6G) displays an atypical absorption profile with two peak plasma concentrations. A proposed explanation is that M6G is hydrolysed to morphine in the colon, which is then absorbed and subsequently undergoes metabolism in the liver to morphine-3-glucuronide (M3G) and M6G. The aims of this study were to confirm and elucidate the biphasic absorption profile as well as clarify the conversion of M6G to morphine after a single oral administration of M6G in healthy volunteers.",

keywords = "Absorption, Administration, Oral, Adolescent, Adult, Analgesics, Opioid, Cross-Over Studies, Humans, Hydrolysis, Male, Morphine, Morphine Derivatives",

author = "Villesen, {Hanne H} and Kim Kristensen and Hansen, {Steen H} and Niels-Henrik Jensen and Ulrik Skram and Christrup, {Lona Louring}",

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language = "English",

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TY - JOUR

T1 - Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers

AU - Villesen, Hanne H

AU - Kristensen, Kim

AU - Hansen, Steen H

AU - Jensen, Niels-Henrik

AU - Skram, Ulrik

AU - Christrup, Lona Louring

PY - 2007/8/1

Y1 - 2007/8/1

N2 - After oral administration, morphine-6-glucuronide (M6G) displays an atypical absorption profile with two peak plasma concentrations. A proposed explanation is that M6G is hydrolysed to morphine in the colon, which is then absorbed and subsequently undergoes metabolism in the liver to morphine-3-glucuronide (M3G) and M6G. The aims of this study were to confirm and elucidate the biphasic absorption profile as well as clarify the conversion of M6G to morphine after a single oral administration of M6G in healthy volunteers.

AB - After oral administration, morphine-6-glucuronide (M6G) displays an atypical absorption profile with two peak plasma concentrations. A proposed explanation is that M6G is hydrolysed to morphine in the colon, which is then absorbed and subsequently undergoes metabolism in the liver to morphine-3-glucuronide (M3G) and M6G. The aims of this study were to confirm and elucidate the biphasic absorption profile as well as clarify the conversion of M6G to morphine after a single oral administration of M6G in healthy volunteers.

KW - Absorption

KW - Administration, Oral

KW - Adolescent

KW - Adult

KW - Analgesics, Opioid

KW - Cross-Over Studies

KW - Humans

KW - Hydrolysis

KW - Male

KW - Morphine

KW - Morphine Derivatives

U2 - 10.1007/s00228-007-0306-4

DO - 10.1007/s00228-007-0306-4

M3 - Journal article

C2 - 17541571

SN - 0031-6970

VL - 63

SP - 761

EP - 767

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

IS - 8

ER -

Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers

Abstract

Keywords

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