Keyphrases
Analgesic Effect
100%
Intravenous Infusion
100%
Morphine
100%
Human Volunteers
100%
Antihyperalgesic Effect
100%
Pharmacokinetic-pharmacodynamic Modeling
100%
Electrical Pain
83%
Pain Tolerance
83%
Placebo
33%
Pharmacodynamics
33%
Healthy Individuals
16%
Placebo-controlled Study
16%
Plasma Concentration
16%
Randomized Double-blind
16%
Modeling Approach
16%
Pharmacokinetics
16%
Human Pain Model
16%
Placebo Treatment
16%
Pain Assessment
16%
Cutaneous Pain
16%
Pain Sensitivity
16%
Secondary Hyperalgesia
16%
Heat Injury
16%
OPRM1
16%
Between-subject Variability
16%
Equilibration
16%
Site Effects
16%
Negligible Effects
16%
Sensitive Subjects
16%
Tolerance Value
16%
Pain Genetics
16%
Allometric Scaling
16%
Quadratic Model
16%
Concentrations-time Profiles
16%
Covariate Effect
16%
Model Discrimination
16%
Pharmacology, Toxicology and Pharmaceutical Science
Analgesic Agent
100%
Pharmacokinetics
100%
Morphine
100%
Pharmacodynamic Modeling
100%
Placebo
50%
Pharmacodynamics
33%
Placebo-Controlled Study
16%
Skin Pain
16%
Experimental Pain
16%
Hyperalgesia
16%
Heat Injury
16%