Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment

P Tfelt-Hansen; L Edvinsson

doi:10.1111/j.1468-2982.2007.01372.x

Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment

P Tfelt-Hansen, L Edvinsson

Department of Clinical Experimental Research

11 Citations (Scopus)

Abstract

The pharmacokinetics of antimigraine drugs zolmitriptan and sumatriptan varied considerably with a fourfold to 10-fold variation in plasma levels. In addition, the pharmacodynamics of triptans as investigated in vitro also varied considerably. In theory, there should probably be a 10-fold variation in doses available, but in clinical practice a fourfold difference in doses will probably cover the needs of most patients.

Original language	English
Journal	Cephalalgia : an international journal of headache
Volume	27
Issue number	10
Pages (from-to)	1091-3
Number of pages	3
ISSN	0333-1024
DOIs	https://doi.org/10.1111/j.1468-2982.2007.01372.x
Publication status	Published - Oct 2007

Keywords

Biological Availability
Cerebral Arteries
Dose-Response Relationship, Drug
Humans
Migraine Disorders
Serotonin Receptor Agonists

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10.1111/j.1468-2982.2007.01372.x

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KW - Cerebral Arteries

KW - Dose-Response Relationship, Drug

KW - Humans

KW - Migraine Disorders

KW - Serotonin Receptor Agonists

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Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment

Abstract

Keywords

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