Pharmacogenetics of antiemetics for chemotherapy-induced nausea and vomiting: A systematic review and meta-analysis

Astrid Eliasen, Kim Dalhoff, René Mathiasen, Kjeld Schmiegelow, Catherine Rechnitzer, Astrid Blicher Schelde, Dyah Aryani Perwitasari, Daiki Tsuji, Jesper Brok

13 Citations (Scopus)

Abstract

A substantial proportion of cancer patients experience chemotherapy-induced nausea and vomiting (CINV) despite the use of antiemetic drugs. Prevalent genetic polymorphisms involved in antiemetic drug metabolism, drug transport and receptor pathways likely affect the effectiveness of antiemetics. Knowledge on which polymorphisms to integrate into individualised clinical care is needed. We did a systematic review evaluating the association between polymorphisms and effectiveness of antiemetics in cancer patients receiving moderately to highly emetogenic chemotherapy. Twenty studies n = 2331 evaluated eight polymorphisms in five candidate genes involved in 5-HT3 antagonist pathways. HTR3C C1214G increased the risk of acute chemotherapy-induced vomiting in the dominant model (odds ratio (OR) = 2.67, 95 % confidence interval (CI): 1.08-6.63). ABCB1 C3435T reduced the risk of acute CINV in the recessive model (OR = 0.60, 95 % CI: 0.44-0.81). Future studies should evaluate candidate genes that affect pharmacogenetics of other antiemetics beside 5-HT3 antagonists.

Original languageEnglish
JournalCritical Reviews in Oncology/Hematology
Volume149
Pages (from-to)102939
ISSN1040-8428
DOIs
Publication statusPublished - May 2020

Keywords

  • Antiemetics
  • Antineoplastic agents
  • Genetic polymorphism
  • Meta-analysis
  • Nausea
  • Neoplasms
  • Vomiting
  • Pharmacogenetics
  • Nausea/chemically induced
  • Humans
  • Cytochrome P-450 Enzyme System/drug effects
  • Neoplasms/drug therapy
  • Receptors, Serotonin, 5-HT3/drug effects
  • Polymorphism, Genetic/genetics
  • Vomiting/chemically induced
  • Serotonin 5-HT3 Receptor Antagonists/therapeutic use
  • Antineoplastic Agents/adverse effects
  • Antiemetics/therapeutic use

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