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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Pharmacoepidemiological methods for computing the duration of pharmacological prescriptions using secondary data sources

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  • Marianne Meaidi
  • Henrik Støvring
  • Klaus Rostgaard
  • Christian Torp-Pedersen
  • Kristian Hay Kragholm
  • Morten Andersen
  • Maurizio Sessa
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PURPOSE: In pharmacoepidemiology, correctly defining the exposure period of pharmacological treatment is a challenging step when information on the time in treatment is missing or incomplete.

METHODS: In this review, we describe several methods for defining exposure to pharmacological treatments using secondary data sources that lack such information.

RESULTS AND CONCLUSION: Several methods for assessing the duration of redeemed prescriptions and combining them into temporal sequences are available. We present a set of considerations to make researchers aware of the potentials and pitfalls of these methods that may aid in minimizing biases in research using these methods. Additionally, we highlight that, to date, there is no one-size-fits-all solution. Thus, the choice of method should be based on their area of applicability combined with a careful mapping to the research scenario under investigation.

Original languageEnglish
JournalEuropean Journal of Clinical Pharmacology
Volume77
Issue number12
Pages (from-to)1805-1814
Number of pages10
ISSN0031-6970
DOIs
Publication statusPublished - Dec 2021

    Research areas

  • Pharmacoepidemiology, Treatment episode duration, Secondary data sources, Adherence, Persistence

ID: 66609436