Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

PfEMP1 - A Parasite Protein Family of Key Importance in Plasmodium falciparum Malaria Immunity and Pathogenesis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Reliable cell and tissue morphology-based diagnosis of endemic Burkitt lymphoma in resource-constrained settings in Ghana

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Looking for Needles in the Plasmodial Haystack

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Plasmodium falciparum causes the most severe form of malaria and is responsible for essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes infected by mature P. falciparum parasites can lead to circulatory disturbances and inflammation, and is thought to be a central element in the pathogenesis of the disease. It is mediated by the interaction of parasite ligands on the erythrocyte surface and a range of host receptor molecules in many organs and tissues. Among several proteins and protein families implicated in this process, the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of high-molecular weight and highly variable antigens appears to be the most prominent. In this chapter, we aim to provide a systematic overview of the current knowledge about these proteins, their structure, their function, how they are presented on the erythrocyte surface, and how the var genes encoding them are regulated. The role of PfEMP1 in the pathogenesis of malaria, PfEMP1-specific immune responses, and the prospect of PfEMP1-specific vaccination against malaria are also covered briefly.

Original languageEnglish
Book seriesAdvances in Parasitology
Pages (from-to)51-84
Number of pages34
Publication statusPublished - Apr 2015

    Research areas

  • Animals, Antigens, Protozoan, Erythrocytes, Gene Expression Regulation, Host-Parasite Interactions, Humans, Malaria, Falciparum, Membrane Proteins, Plasmodium falciparum, Protozoan Proteins

ID: 45787622