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The Capital Region of Denmark - a part of Copenhagen University Hospital
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PfEMP1 - A Parasite Protein Family of Key Importance in Plasmodium falciparum Malaria Immunity and Pathogenesis

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  1. Reliable cell and tissue morphology-based diagnosis of endemic Burkitt lymphoma in resource-constrained settings in Ghana

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  2. Looking for Needles in the Plasmodial Haystack

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  3. Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG

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Plasmodium falciparum causes the most severe form of malaria and is responsible for essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes infected by mature P. falciparum parasites can lead to circulatory disturbances and inflammation, and is thought to be a central element in the pathogenesis of the disease. It is mediated by the interaction of parasite ligands on the erythrocyte surface and a range of host receptor molecules in many organs and tissues. Among several proteins and protein families implicated in this process, the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of high-molecular weight and highly variable antigens appears to be the most prominent. In this chapter, we aim to provide a systematic overview of the current knowledge about these proteins, their structure, their function, how they are presented on the erythrocyte surface, and how the var genes encoding them are regulated. The role of PfEMP1 in the pathogenesis of malaria, PfEMP1-specific immune responses, and the prospect of PfEMP1-specific vaccination against malaria are also covered briefly.

Original languageEnglish
Book seriesAdvances in Parasitology
Volume88
Pages (from-to)51-84
Number of pages34
ISSN0065-308X
DOIs
Publication statusPublished - Apr 2015

    Research areas

  • Animals, Antigens, Protozoan, Erythrocytes, Gene Expression Regulation, Host-Parasite Interactions, Humans, Malaria, Falciparum, Membrane Proteins, Plasmodium falciparum, Protozoan Proteins

ID: 45787622