Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

PET/CT prior to salvage surgery in recurrent head and neck squamous cell carcinoma

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Decentralized virtual reality mastoidectomy simulation training: a prospective, mixed-methods study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Positive pressure device treatment for Menière's disease: an overview of the current evidence and a meta-analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Procedure-specific assessment tool for flexible pharyngo-laryngoscopy: gathering validity evidence and setting pass-fail standards

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Diagnostic flexible pharyngo-laryngoscopy: development of a procedure specific assessment tool using a Delphi methodology

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. European status on temporal bone training: a questionnaire study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Dynamic soft tissue changes in the orbit after a blowout fracture

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Incidence and survival of hypopharyngeal cancer: a Danish Nation-Wide Study from 1980 to 2014

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Near-infrared fluorescence imaging improves the nodal yield in neck dissection in oral cavity cancer - A randomized study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Perspektiver på recidiverende respiratorisk papillomatose og humant papillomvirus-vaccination

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

PURPOSE: The purpose of this study was to assess the use of 18F-FDG PET/CT scans for detecting distant metastases in patients with recurrent head and neck squamous cell carcinoma (HNSCC) and investigate the treatment and survival of patients with recurrence.

METHODS: In this retrospective study, consecutive head and neck cancer patients referred for FDG PET/CT scan between 2012 and 2014 were included. Patient records were reviewed and only patients with recurrence of HNSCC were enrolled for further analysis. Information on distant metastases, surgery and survival was collected. A Kaplan-Meier analysis was used to report survival.

RESULTS: Overall 275 PET/CT scans were performed due to suspected recurrence, and in 166 scans (144 patients), recurrence of HNSCC was confirmed, making them eligible for further analysis. Distant metastases were revealed in 29.8% of the scans (n = 51) and the proportion of revealed metastases remained constant at approximately 30% each year. Although the number of performed scans increased twofold each year, there was no statistically significant change in the proportion of scans with distant metastasis (p = 0.55). The distant metastases were most often seen in the lungs (n = 44) and bone (n = 15). A few patients had widespread dissemination to other areas. Salvage surgery was performed following 81 of the 166 PET/CT scans. Seven of the patients who underwent salvage surgery had M-site oligo-metastases. Patients who underwent salvage surgery had a median survival of 22 months whereas patients not treated with salvage surgery had a median survival of 6 months. After 5 years, 21% of the patients selected for salvage surgery were alive.

CONCLUSIONS: Distant metastases occur frequently in patients with recurrent HNSCC disease and the proportion of revealed distant metastases remained the same (30%). Imaging with FDG PET/CT can be recommended in patients with recurrent HNSCC prior to putative salvage surgery.

Original languageEnglish
JournalEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Volume276
Issue number10
Pages (from-to)2895-2902
Number of pages8
ISSN0003-9195
DOIs
Publication statusPublished - Oct 2019

ID: 58056223