PET/CT imaging in response evaluation of patients with small cell lung cancer

Abstract

UNLABELLED: There is an increasing amount of evidence on the usability of PET in response evaluation of non-small cell lung cancer. However, data on SCLC is scarce and mainly retrospective. This prospective study assesses the use of PET (positron emission tomography) and PET/CT in response evaluation of patients with small cell lung cancer (SCLC).

METHODS: Assignment of early and final response was compared between PET, PET/CT, and CT in 20 patients with SCLC. Final response as assigned by CT (RECIST) served as reference.

RESULTS: At response evaluation after one cycle of chemotherapy major disagreement (responder versus non-responder) between PET and CT in predicting final response was seen in 1 of 12 patients. At final response evaluation major disagreement between PET, PET/CT and CT was seen in 2 of 19 patients (11%). All measurements of FDG-uptake were significantly correlated to size and changes in size as measured by CT. A significant difference in relative change in tumour FDG-uptake and volume was found between responding and non-responding patients. No significant difference was found between a visual and semi-quantitative analysis of PET.

CONCLUSION: Response evaluation of SCLC by PET/CT is feasible, but it is uncertain whether it adds further information to evaluation by RECIST, thus further studies and standardization of methods are needed.

Original languageEnglish
JournalLung Cancer
Volume54
Issue number1
Pages (from-to)41-9
Number of pages9
ISSN0169-5002
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Aged
  • Carcinoma, Small Cell/diagnostic imaging
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Lung Neoplasms/diagnostic imaging
  • Male
  • Middle Aged
  • Positron-Emission Tomography
  • Predictive Value of Tests
  • Prospective Studies
  • Radiography
  • Radiopharmaceuticals
  • Risk Assessment
  • Risk Factors
  • Statistics, Nonparametric
  • Tomography, Emission-Computed
  • Treatment Outcome

Fingerprint

Dive into the research topics of 'PET/CT imaging in response evaluation of patients with small cell lung cancer'. Together they form a unique fingerprint.

Cite this