Personalization of Multi-electrode Setups in tCS/tES: Methods and Advantages

R. Salvador; M. C. Biagi; O. Puonti; M. Splittgerber; V. Moliadze; M. Siniatchkin; A. Thielscher; G. Ruffini

doi:10.1007/978-3-030-45623-8_7

Personalization of Multi-electrode Setups in tCS/tES: Methods and Advantages

R. Salvador, M. C. Biagi, O. Puonti, M. Splittgerber, V. Moliadze, M. Siniatchkin, A. Thielscher, G. Ruffini

Abstract

Transcranial current stimulation (tCS or tES) protocols yield results that are highly variable across individuals. Part of this variability results from differences in the electric field (E-field) induced in subjects’ brains during stimulation. The E-field determines how neurons respond to stimulation, and it can be used as a proxy for predicting the concurrent effects of stimulation, like changes in cortical excitability, and, ultimately, its plastic effects. While the use of multichannel systems with small electrodes has provided a more precise tool for delivering tCS, individually variable anatomical parameters like the shape and thickness of tissues affect the E-field distribution for a specific electrode montage. Therefore, using the same montage parameters across subjects does not lead to the homogeneity of E-field amplitude over the desired targets. Here we describe a pipeline that leverages individualized head models combined with montage optimization algorithms to reduce the variability of the E-field distributions over subjects in tCS. We will describe the different steps of the pipeline – namely, MRI segmentation and head model creation, target specification, and montage optimization – and discuss their main advantages and limitations.

Original language	English
Title of host publication	Brain and Human Body Modeling 2020: Computational Human Models Presented at EMBC 2019 and the BRAIN Initiative® 2019 Meeting
Editors	Sergey N. Makarov, Gregory M. Noetscher, Aapo Nummenmaa
Number of pages	17
Place of Publication	Gewerbestrasse 11, 6330 Cham, Switzerland
Publisher	Springer International Publishing AG
Publication date	2020
Pages	119-135
ISBN (Print)	978-3-030-45622-1
ISBN (Electronic)	978-3-030-45623-8
DOIs	https://doi.org/10.1007/978-3-030-45623-8_7
Publication status	Published - 2020
Event	41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Berlin, Germany Duration: 23 Jul 2019 → 27 Jul 2019

Conference

Conference	41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Country/Territory	Germany
City	Berlin
Period	23/07/2019 → 27/07/2019

Access to Document

10.1007/978-3-030-45623-8_7

Cite this

Salvador, R., Biagi, M. C., Puonti, O., Splittgerber, M., Moliadze, V., Siniatchkin, M., Thielscher, A., & Ruffini, G. (2020). Personalization of Multi-electrode Setups in tCS/tES: Methods and Advantages. In S. N. Makarov, G. M. Noetscher, & A. Nummenmaa (Eds.), Brain and Human Body Modeling 2020: Computational Human Models Presented at EMBC 2019 and the BRAIN Initiative® 2019 Meeting (pp. 119-135). Springer International Publishing AG. https://doi.org/10.1007/978-3-030-45623-8_7

Personalization of Multi-electrode Setups in tCS/tES: Methods and Advantages. / Salvador, R.; Biagi, M. C.; Puonti, O. et al.
Brain and Human Body Modeling 2020: Computational Human Models Presented at EMBC 2019 and the BRAIN Initiative® 2019 Meeting. ed. / Sergey N. Makarov; Gregory M. Noetscher; Aapo Nummenmaa. Gewerbestrasse 11, 6330 Cham, Switzerland: Springer International Publishing AG, 2020. p. 119-135.

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Salvador, R, Biagi, MC, Puonti, O, Splittgerber, M, Moliadze, V, Siniatchkin, M, Thielscher, A & Ruffini, G 2020, Personalization of Multi-electrode Setups in tCS/tES: Methods and Advantages. in SN Makarov, GM Noetscher & A Nummenmaa (eds), Brain and Human Body Modeling 2020: Computational Human Models Presented at EMBC 2019 and the BRAIN Initiative® 2019 Meeting. Springer International Publishing AG, Gewerbestrasse 11, 6330 Cham, Switzerland, pp. 119-135, 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Berlin, Germany, 23/07/2019. https://doi.org/10.1007/978-3-030-45623-8_7

Salvador R, Biagi MC, Puonti O, Splittgerber M, Moliadze V, Siniatchkin M et al. Personalization of Multi-electrode Setups in tCS/tES: Methods and Advantages. In Makarov SN, Noetscher GM, Nummenmaa A, editors, Brain and Human Body Modeling 2020: Computational Human Models Presented at EMBC 2019 and the BRAIN Initiative® 2019 Meeting. Gewerbestrasse 11, 6330 Cham, Switzerland: Springer International Publishing AG. 2020. p. 119-135 doi: 10.1007/978-3-030-45623-8_7

Salvador, R. ; Biagi, M. C. ; Puonti, O. et al. / Personalization of Multi-electrode Setups in tCS/tES : Methods and Advantages. Brain and Human Body Modeling 2020: Computational Human Models Presented at EMBC 2019 and the BRAIN Initiative® 2019 Meeting. editor / Sergey N. Makarov ; Gregory M. Noetscher ; Aapo Nummenmaa. Gewerbestrasse 11, 6330 Cham, Switzerland : Springer International Publishing AG, 2020. pp. 119-135

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abstract = "Transcranial current stimulation (tCS or tES) protocols yield results that are highly variable across individuals. Part of this variability results from differences in the electric field (E-field) induced in subjects{\textquoteright} brains during stimulation. The E-field determines how neurons respond to stimulation, and it can be used as a proxy for predicting the concurrent effects of stimulation, like changes in cortical excitability, and, ultimately, its plastic effects. While the use of multichannel systems with small electrodes has provided a more precise tool for delivering tCS, individually variable anatomical parameters like the shape and thickness of tissues affect the E-field distribution for a specific electrode montage. Therefore, using the same montage parameters across subjects does not lead to the homogeneity of E-field amplitude over the desired targets. Here we describe a pipeline that leverages individualized head models combined with montage optimization algorithms to reduce the variability of the E-field distributions over subjects in tCS. We will describe the different steps of the pipeline – namely, MRI segmentation and head model creation, target specification, and montage optimization – and discuss their main advantages and limitations.",

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AB - Transcranial current stimulation (tCS or tES) protocols yield results that are highly variable across individuals. Part of this variability results from differences in the electric field (E-field) induced in subjects’ brains during stimulation. The E-field determines how neurons respond to stimulation, and it can be used as a proxy for predicting the concurrent effects of stimulation, like changes in cortical excitability, and, ultimately, its plastic effects. While the use of multichannel systems with small electrodes has provided a more precise tool for delivering tCS, individually variable anatomical parameters like the shape and thickness of tissues affect the E-field distribution for a specific electrode montage. Therefore, using the same montage parameters across subjects does not lead to the homogeneity of E-field amplitude over the desired targets. Here we describe a pipeline that leverages individualized head models combined with montage optimization algorithms to reduce the variability of the E-field distributions over subjects in tCS. We will describe the different steps of the pipeline – namely, MRI segmentation and head model creation, target specification, and montage optimization – and discuss their main advantages and limitations.

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ER -

Personalization of Multi-electrode Setups in tCS/tES: Methods and Advantages

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