Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Peroral versus intravenous post-operative antibiotics after surgery for complicated appendicitis: protocol for a cluster-randomised cluster-crossover non-inferiority study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Reduction in maternal mortality in Denmark over three decades

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. An audit of 70 maternal deaths

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Criteria-based dispatch of emergency medical services in non-traumatic subarachnoid haemorrhage

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Characteristics of patients reporting symptoms by open-ended questions in specialist palliative care

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Accuracy of preoperative staging with multidetector computed tomography in colon cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Triage May Improve Selection to Colonoscopy and Reduce the Number of Unnecessary Colonoscopies

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Quality of recovery after major emergency abdominal surgery. A prospective observational cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Validity of the diagnosis of appendicitis in the Danish National Patient Register

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION: Complicated appendicitis increases the risk of post-operative intra-abdominal abscess. Treatment of complicated appendicitis is usually a post-operative course of intravenous antibiotics. A study is needed to confirm the results of retrospective studies showing that a post-operative course of oral antibiotics is not inferior to intravenous antibiotics after laparoscopic surgery for complicated appendicitis.

METHODS: The Per oral versus Intravenous Postoperative Antibiotics after surgery for complicated appendicitis (PIPA) trial will be a prospective, multicentre, cluster-randomised cluster-crossover non-inferiority study designed to test whether a three-day post-operative course of oral antibiotics is non-inferior to a three-day post-operative course of intravenous antibiotics as standard care after laparoscopic surgery for complicated appendicitis in regards to the risk of post-operative intra-abdominal abscess formation within 30 days. Participating hospitals will either be randomised to a six-month period with an oral antibiotic regime followed by a six-month period with an intravenous antibiotic regime for the post-operative treatment after laparoscopic surgery for complicated appendicitis, or to a six-month period with an intravenous antibiotic regime followed by a six-month period with an oral antibiotic regime for post-operative treatment after laparoscopic surgery for complicated appendicitis.

CONCLUSIONS: The primary outcome will be the incidence of intra-abdominal abscess by post-operative day 30.

FUNDING: none.

TRIAL REGISTRATION: The study was approved by the Danish Data Protection Agency and by the National/Regional Committee on Health Research Ethics.

Original languageEnglish
Article numberA12200917
JournalDanish Medical Journal
Volume68
Issue number6
ISSN1603-9629
Publication statusPublished - 28 May 2021

    Research areas

  • Abdominal Abscess/drug therapy, Anti-Bacterial Agents/therapeutic use, Appendectomy/adverse effects, Appendicitis/drug therapy, Humans, Multicenter Studies as Topic, Prospective Studies, Randomized Controlled Trials as Topic, Retrospective Studies, Treatment Outcome

ID: 66405632