Permanent distal occlusion of middle cerebral artery in rat causes local increased ETB, 5-HT₁B and AT₁ receptor-mediated contractility downstream of occlusion

Marianne N P Rasmussen; Malene Hornbak; Stine S Larsen; Majid Sheykhzade; Lars Edvinsson

doi:10.1159/000354242

Permanent distal occlusion of middle cerebral artery in rat causes local increased ETB, 5-HT₁B and AT₁ receptor-mediated contractility downstream of occlusion

Marianne N P Rasmussen, Malene Hornbak, Stine S Larsen, Majid Sheykhzade, Lars Edvinsson

Department of Clinical Experimental Research

9 Citations (Scopus)

Abstract

In response to experimental stroke, a characteristic functional and expressional upregulation of contractile G-protein-coupled receptors has been uncovered in the affected cerebral vasculature; however, the mechanism initiating this phenomenon remains unknown.

Original language	English
Journal	Journal of Vascular Research
Volume	50
Issue number	5
Pages (from-to)	396-409
Number of pages	14
ISSN	1018-1172
DOIs	https://doi.org/10.1159/000354242
Publication status	Published - 2013

Keywords

Animals
Infarction, Middle Cerebral Artery
Male
Middle Cerebral Artery
Muscle Contraction
Myography
Rats
Receptor, Angiotensin, Type 1
Receptor, Endothelin B
Receptor, Serotonin, 5-HT1B
Stroke
Vasoconstriction
Viper Venoms

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10.1159/000354242

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Permanent distal occlusion of middle cerebral artery in rat causes local increased ETB, 5-HT₁B and AT₁ receptor-mediated contractility downstream of occlusion. / Rasmussen, Marianne N P; Hornbak, Malene; Larsen, Stine S et al.
In: Journal of Vascular Research, Vol. 50, No. 5, 2013, p. 396-409.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Permanent distal occlusion of middle cerebral artery in rat causes local increased ETB, 5-HT₁B and AT₁ receptor-mediated contractility downstream of occlusion",

abstract = "In response to experimental stroke, a characteristic functional and expressional upregulation of contractile G-protein-coupled receptors has been uncovered in the affected cerebral vasculature; however, the mechanism initiating this phenomenon remains unknown.",

keywords = "Animals, Infarction, Middle Cerebral Artery, Male, Middle Cerebral Artery, Muscle Contraction, Myography, Rats, Receptor, Angiotensin, Type 1, Receptor, Endothelin B, Receptor, Serotonin, 5-HT1B, Stroke, Vasoconstriction, Viper Venoms",

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AU - Rasmussen, Marianne N P

AU - Hornbak, Malene

AU - Larsen, Stine S

AU - Sheykhzade, Majid

AU - Edvinsson, Lars

PY - 2013

Y1 - 2013

N2 - In response to experimental stroke, a characteristic functional and expressional upregulation of contractile G-protein-coupled receptors has been uncovered in the affected cerebral vasculature; however, the mechanism initiating this phenomenon remains unknown.

AB - In response to experimental stroke, a characteristic functional and expressional upregulation of contractile G-protein-coupled receptors has been uncovered in the affected cerebral vasculature; however, the mechanism initiating this phenomenon remains unknown.

KW - Animals

KW - Infarction, Middle Cerebral Artery

KW - Male

KW - Middle Cerebral Artery

KW - Muscle Contraction

KW - Myography

KW - Rats

KW - Receptor, Angiotensin, Type 1

KW - Receptor, Endothelin B

KW - Receptor, Serotonin, 5-HT1B

KW - Stroke

KW - Vasoconstriction

KW - Viper Venoms

UR - https://www.scopus.com/pages/publications/84886794102

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DO - 10.1159/000354242

M3 - Journal article

C2 - 23988741

SN - 1018-1172

VL - 50

SP - 396

EP - 409

JO - Journal of Vascular Research

JF - Journal of Vascular Research

IS - 5

ER -

Permanent distal occlusion of middle cerebral artery in rat causes local increased ETB, 5-HT₁B and AT₁ receptor-mediated contractility downstream of occlusion

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