Perisylvian epileptic network revisited

Péter Halász, Anna Kelemen, Bea Rosdy, György Rásonyi, Béla Clemens, Anna Szűcs

19 Citations (Scopus)


We overview here the new data about the epileptic spectrum disorders within the frame of perisylvian epileptic network since our first trial to synthetize knowledge about this system epilepsy (Halász et al., 2005). We found evidences for a continual features relating together syndromes constituting this spectrum disorder in several fields: in sharing genetic origin, in common perisylvian human communication circuitry, in NREM sleep related potentiation of interictal epileptiform discharges of the centro-temporal spike phenomenon and in the discharge related cognitive impairment, reflecting functional deficits in human communication abilities. The transformation of a part of the children to develop into a malignant course with different degree of residual cognitive loss, through compromising sleep plastic functions, by the epileptic discharges during sleep, beside pure genetic origin, is still under research. Both factual data and new conceptual approaches helps understand better the developmental childhood epilepsies.

Original languageEnglish
Pages (from-to)31-41
Number of pages11
Publication statusPublished - 1 Feb 2019


  • Centro-temporal spike phenomenon
  • Childhood developmental epilepsies
  • Cognitive impairment
  • Electrical Status epilepticus in sleep
  • Landau-Kleffner syndrome
  • NREM sleep potentiation of interictal epileptic discharges
  • Panayiotopoulos syndrome
  • Perisylvian human communication network
  • Rolandic epilepsy
  • Spectrum disorders


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