Perioperativ heparin-bridging er sjældent indiceret

Jørn Dalsgaard Nielsen; Anna-Marie Bloch Münster; Steen Elkjær Husted

Perioperativ heparin-bridging er sjældent indiceret

Translated title of the contribution: Perioperative heparin bridging is rarely indicated

Jørn Dalsgaard Nielsen, Anna-Marie Bloch Münster, Steen Elkjær Husted

Department of Cardiology

Abstract

Meta-analyses of cohort studies and a recent randomized, placebo-controlled study have shown that perioperative bridging of warfarin therapy with therapeutic doses of heparin results in a multi-fold increase in major bleeding but no reduction in the incidence of thromboembolism. It is time to reconsider heparin bridging: When is heparin bridging superfluous? When is prophylactic dosage indicated? And when is it safe to use therapeutic dosing?

Translated title of the contribution	Perioperative heparin bridging is rarely indicated
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	178
Issue number	9
Pages (from-to)	V12150952
ISSN	0041-5782
Publication status	Published - 29 Feb 2016

Cite this

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title = "Perioperativ heparin-bridging er sj{\ae}ldent indiceret",

abstract = "Meta-analyses of cohort studies and a recent randomized, placebo-controlled study have shown that perioperative bridging of warfarin therapy with therapeutic doses of heparin results in a multi-fold increase in major bleeding but no reduction in the incidence of thromboembolism. It is time to reconsider heparin bridging: When is heparin bridging superfluous? When is prophylactic dosage indicated? And when is it safe to use therapeutic dosing? ",

keywords = "Anticoagulants/administration \& dosage, Hemorrhage/chemically induced, Heparin/administration \& dosage, Heparin, Low-Molecular-Weight/administration \& dosage, Humans, Perioperative Care, Thromboembolism/prevention \& control, Vitamin K/antagonists \& inhibitors, Warfarin/administration \& dosage",

author = "Nielsen, \{J{\o}rn Dalsgaard\} and M{\"u}nster, \{Anna-Marie Bloch\} and Husted, \{Steen Elkj{\ae}r\}",

year = "2016",

month = feb,

day = "29",

language = "Dansk",

volume = "178",

pages = "V12150952",

journal = "Ugeskrift for Laeger",

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TY - JOUR

T1 - Perioperativ heparin-bridging er sjældent indiceret

AU - Nielsen, Jørn Dalsgaard

AU - Münster, Anna-Marie Bloch

AU - Husted, Steen Elkjær

PY - 2016/2/29

Y1 - 2016/2/29

N2 - Meta-analyses of cohort studies and a recent randomized, placebo-controlled study have shown that perioperative bridging of warfarin therapy with therapeutic doses of heparin results in a multi-fold increase in major bleeding but no reduction in the incidence of thromboembolism. It is time to reconsider heparin bridging: When is heparin bridging superfluous? When is prophylactic dosage indicated? And when is it safe to use therapeutic dosing?

AB - Meta-analyses of cohort studies and a recent randomized, placebo-controlled study have shown that perioperative bridging of warfarin therapy with therapeutic doses of heparin results in a multi-fold increase in major bleeding but no reduction in the incidence of thromboembolism. It is time to reconsider heparin bridging: When is heparin bridging superfluous? When is prophylactic dosage indicated? And when is it safe to use therapeutic dosing?

KW - Anticoagulants/administration & dosage

KW - Hemorrhage/chemically induced

KW - Heparin/administration & dosage

KW - Heparin, Low-Molecular-Weight/administration & dosage

KW - Humans

KW - Perioperative Care

KW - Thromboembolism/prevention & control

KW - Vitamin K/antagonists & inhibitors

KW - Warfarin/administration & dosage

UR - https://www.scopus.com/pages/publications/85056732440

M3 - Review

C2 - 26957485

SN - 0041-5782

VL - 178

SP - V12150952

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 9

ER -

Perioperativ heparin-bridging er sjældent indiceret

Abstract

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