Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins

Research output: Contribution to journalJournal articleResearchpeer-review


  1. Bone turnover markers during the remission phase in children and adolescents with type 1 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Estimates of prediabetes and undiagnosed type 2 diabetes in Denmark: The end of an epidemic or a diagnostic artefact?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Evidence of immune elimination, immuno-editing and immune escape in patients with hematological cancer

    Research output: Contribution to journalReviewResearchpeer-review

  4. Screening for retinopathy in children with type 1 diabetes in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

(1) Background: Zinc is an essential micronutrient and zinc deficiency is associated with immune dysfunction. The neonatal immune system is immature, and therefore an optimal neonatal zinc status may be important. The aim of this study was to investigate the possible association between neonatal whole blood (WB)-Zinc content and several immune markers. (2) Methods: In total, 398 healthy newborns (199 who later developed type 1 diabetes and 199 controls) from the Danish Newborn Screening Biobank had neonatal dried blood spots (NDBS) analyzed for WB-Zinc content and (i) cytokines: Interleukin (IL)-1β, IL-4, IL-6, IL-8, IL-10, IL-12 (p70), interferon gamma, tumor necrosis factor alpha, and transforming growth factor beta; (ii) adipokines: leptin and adiponectin; (iii) other immune response proteins: C-reactive protein (CRP), and mannose-binding lectin (MBL), and soluble triggering receptors expressed on myeloid cells1 (sTREM-1). WB-Zinc content was determined using laser ablation inductively coupled plasma mass spectrometry. For each analyte, the relative change in mean level was modelled by a robust log-normal model regression. (3) Results: No association was found between WB-Zinc content and all the immune response markers in either the unadjusted or adjusted models overall or when stratifying by case status. (4) Conclusions: In healthy Danish neonates, WB-Zinc content was not associated with cytokines, adipokines, CRP, MBL or sTREM, which does not indicate a strong immunological function of neonatal zinc status.

Original languageEnglish
Article number1980
Issue number9
Publication statusPublished - 22 Aug 2019

    Research areas

  • Adipokines, C-reactive protein, Cytokines, Immune system, Infant, Mannose-binding lectin, Newborn, TREM1, Zinc

ID: 57976067