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The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Pericardial adipose tissue volume is independently associated with HIV status and prior use of stavudine, didanosine or indinavir

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BACKGROUND: Increased pericardial adipose tissue is associated with higher risk of cardiovascular disease. We aimed to determine if HIV status was independently associated with larger pericardial adipose tissue volume and to explore possible HIV-specific risk factors.

METHODS: Persons with HIV (PWH) were recruited from the Copenhagen Comorbidity in HIV Infection (COCOMO) Study and matched 1:1 on age and sex to uninfected controls. Pericardial adipose tissue volume was measured using cardiac CT.

RESULTS: A total of 587 PWH and 587 controls were included. Median age was 52 years, 88% were male. HIV status was independently associated with 17 mL (95% confidence interval [10, 23]), p<.001 larger pericardial adipose tissue volume. Larger pericardial adipose tissue volume was associated with low CD4+ nadir and prior use of stavudine, didanosine and indinavir. Among PWH without thymidine analogue or didanosine exposure, time since initiating cART (per 5-year use) was associated with l6 mL [-6, -25] lower pericardial adipose tissue volume, p=.002.

CONCLUSION: HIV status was independently associated with larger pericardial adipose tissue volume. Severe immunodeficiency, stavudine, didanosine and indinavir were associated with larger pericardial adipose tissue volume. PWH with prior exposure to these drugs may constitute a distinct cardiovascular risk population.

Original languageEnglish
JournalThe Journal of infectious diseases
ISSN0022-1899
DOIs
Publication statusE-pub ahead of print - 6 Feb 2020

ID: 59288126