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Periarticular and generalised bone loss in patients with early rheumatoid arthritis: influence of alendronate and intra-articular glucocorticoid treatment. Post hoc analyses from the CIMESTRA trial

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OBJECTIVES: The aims of this study were to investigate the influence of alendronate and intra-articular betamethasone treatment on bone mineral density (BMD) changes in hand, lumbar spine and femoral neck during 1 year of a treat-to-target study (Cyclosporine, Methotrexate, Steroid in RA (CIMESTRA)). PATIENTS AND METHODS: A hundred and sixty patients with early, active rheumatoid arthritis (RA) received methotrexate, intra-articular betamethasone and ciclosporin /placebo-ciclosporin. Patients with Z-score ≤0 also started alendronate 10 mg/day. BMD of the hand (digital x-ray radiogrammetry (DXR-BMDhand)), BMD of lumbar spine and femoral neck (dual x-ray absorptiometry (DXA-BMDlumbar spine and DXA-BMDfemoral neck)) and x-rays of hands, wrists and forefeet (modified Sharp-van der Heijde score) were measured at baseline and 1 year, with complete data available in 107 patients. RESULTS: The change in BMD in hand, lumbar spine and femoral neck was negatively associated with the dose of intra-articular betamethasone (p
Original languageEnglish
JournalAnnals of the Rheumatic Diseases
Volume73
Issue number6
Pages (from-to)1123-1129
Number of pages7
ISSN0003-4967
DOIs
Publication statusPublished - 9 May 2014

Bibliographical note

T W Jensen1,L Hyldstrup1, 1Department of Endocrinology, Copenhagen University Hospital, Hvidovre, Denmark
M S Hansen2,3, J Pødenphant2 L S Andersen2, 2Department of Rheumatology, Copenhagen University Hospital, Gentofte, Denmark 3Reuma Klinik Roskilde, Roskilde, Denmark
K Hørslev-Petersen4, T Lottenburger4 J K Pedersen4
B Abrahamsen5, 5Department of Endocrinology, Copenhagen University Hospital, Gentofte, Denmark Med F
B Langdahl6,
B Zerahn7, 7Department of Clinical Physiology, Copenhagen University Hospital, Herlev, Denmark
, K Stengaard-Petersen8, T Ellingsen8 I Hansen8, U Tarp8,
P Junker9, A J Svendsen9, H Lindegaard9,
M Østergaard10,11, ,, H Skjødt10,, U B Lauridsen10, M L Hetland10,11, 10Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup, Denmark
Anne Grethe Jurik12,
Aage Vestergaard13, 13Department of Radiology, Copenhagen University Hospital, Hvidovre, Denmark
the Cimestra study group,
- Author Affiliations




4Department of Rheumatology, Gigthospitalet, University of Southern Denmark, Gråsten, Denmark

6Department of Endocrinology and Internal Medicine THG, Aarhus University Hospital, Aarhus, Denmark

8Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
9Department of Rheumatology, Odense University Hospital, Odense, Denmark

11Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
12Department of Radiology, Aarhus University Hospital, Aarhus, Denmark


rial
T W Jensen1, M S Hansen2,3, K Hørslev-Petersen4, L Hyldstrup1, B Abrahamsen5, B Langdahl6, B Zerahn7, J Pødenphant2, K Stengaard-Petersen8, P Junker9, M Østergaard10,11, T Lottenburger4, T Ellingsen8, L S Andersen2, I Hansen8, H Skjødt10, J K Pedersen4, U B Lauridsen10, A J Svendsen9, U Tarp8, H Lindegaard9, Anne Grethe Jurik12, Aage Vestergaard13, M L Hetland10,11, the Cimestra study group,
- Author Affiliations

1Department of Endocrinology, Copenhagen University Hospital, Hvidovre, Denmark
2Department of Rheumatology, Copenhagen University Hospital, Gentofte, Denmark
3Reuma Klinik Roskilde, Roskilde, Denmark
4Department of Rheumatology, Gigthospitalet, University of Southern Denmark, Gråsten, Denmark
5Department of Endocrinology, Copenhagen University Hospital, Gentofte, Denmark
6Department of Endocrinology and Internal Medicine THG, Aarhus University Hospital, Aarhus, Denmark
7Department of Clinical Physiology, Copenhagen University Hospital, Herlev, Denmark
8Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
9Department of Rheumatology, Odense University Hospital, Odense, Denmark
10Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup, Denmark
11Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
12Department of Radiology, Aarhus University Hospital, Aarhus, Denmark
13Department of Radiology, Copenhagen University Hospital, Hvidovre, Denmark

ID: 42205321