Performance of 3 rapid tests for discrimination between HIV-1 and HIV-2 in Guinea-Bissau, West Africa

Bo Langhoff Hønge; Magnús Pétur Bjarnason Obinah; Sanne Jespersen; Candida Medina; David da Silva Té; Zacarias José da Silva; Lars Østergaard; Alex Lund Laursen; Christian Wejse; Christian Erikstrup; Bissau HIV cohort study group

doi:10.1097/QAI.0b013e3182a97b81

Performance of 3 rapid tests for discrimination between HIV-1 and HIV-2 in Guinea-Bissau, West Africa

Bo Langhoff Hønge, Magnús Pétur Bjarnason Obinah, Sanne Jespersen, Candida Medina, David da Silva Té, Zacarias José da Silva, Lars Østergaard, Alex Lund Laursen, Christian Wejse, Christian Erikstrup, Bissau HIV cohort study group

Abstract

As HIV-2 is intrinsically resistant to nonnucleoside reverse transcriptase inhibitors, it is mandatory to discriminate between HIV types before initiating antiretroviral treatment. Guinea-Bissau has the world's highest prevalence of HIV-2 and HIV-1/HIV-2 dually infected individuals. We evaluated 3 rapid tests for discrimination between HIV-1, HIV-2, and dual infections among 219 patients from Guinea-Bissau by comparing with the gold standard (INNO-LIA). Genie III HIV-1/HIV-2 was the best performer with regard to discriminatory capacity (agreement 91.8%), followed by Immunoflow HIV1-HIV2 (agreement 90.9%) and SD Bioline HIV-1/2 3.0 (agreement 84.5%). Our results underscore the need for evaluation of tests in relevant populations before implementation.

Original language	English
Journal	Journal of acquired immune deficiency syndromes (1999)
Volume	65
Issue number	1
Pages (from-to)	87-90
Number of pages	4
ISSN	1525-4135
DOIs	https://doi.org/10.1097/QAI.0b013e3182a97b81
Publication status	Published - 1 Jan 2014
Externally published	Yes

Keywords

AIDS Serodiagnosis/methods
Adult
CD4 Lymphocyte Count
Coinfection/diagnosis
Female
Guinea-Bissau/epidemiology
HIV Infections/diagnosis
HIV-1
HIV-2
Humans
Male
Middle Aged
Sensitivity and Specificity

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Hønge, B. L., Bjarnason Obinah, M. P., Jespersen, S., Medina, C., Té, D. D. S., da Silva, Z. J., Østergaard, L., Laursen, A. L., Wejse, C., Erikstrup, C., & Bissau HIV cohort study group (2014). Performance of 3 rapid tests for discrimination between HIV-1 and HIV-2 in Guinea-Bissau, West Africa. Journal of acquired immune deficiency syndromes (1999), 65(1), 87-90. https://doi.org/10.1097/QAI.0b013e3182a97b81

Performance of 3 rapid tests for discrimination between HIV-1 and HIV-2 in Guinea-Bissau, West Africa. / Hønge, Bo Langhoff; Bjarnason Obinah, Magnús Pétur; Jespersen, Sanne et al.
In: Journal of acquired immune deficiency syndromes (1999), Vol. 65, No. 1, 01.01.2014, p. 87-90.

Research output: Contribution to journal › Journal article › Research › peer-review

Hønge, BL, Bjarnason Obinah, MP, Jespersen, S, Medina, C, Té, DDS, da Silva, ZJ, Østergaard, L, Laursen, AL, Wejse, C, Erikstrup, C & Bissau HIV cohort study group 2014, 'Performance of 3 rapid tests for discrimination between HIV-1 and HIV-2 in Guinea-Bissau, West Africa', Journal of acquired immune deficiency syndromes (1999), vol. 65, no. 1, pp. 87-90. https://doi.org/10.1097/QAI.0b013e3182a97b81

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AB - As HIV-2 is intrinsically resistant to nonnucleoside reverse transcriptase inhibitors, it is mandatory to discriminate between HIV types before initiating antiretroviral treatment. Guinea-Bissau has the world's highest prevalence of HIV-2 and HIV-1/HIV-2 dually infected individuals. We evaluated 3 rapid tests for discrimination between HIV-1, HIV-2, and dual infections among 219 patients from Guinea-Bissau by comparing with the gold standard (INNO-LIA). Genie III HIV-1/HIV-2 was the best performer with regard to discriminatory capacity (agreement 91.8%), followed by Immunoflow HIV1-HIV2 (agreement 90.9%) and SD Bioline HIV-1/2 3.0 (agreement 84.5%). Our results underscore the need for evaluation of tests in relevant populations before implementation.

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Performance of 3 rapid tests for discrimination between HIV-1 and HIV-2 in Guinea-Bissau, West Africa

Abstract

Keywords

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