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Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation

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  1. MAIT cell subtypes in multiple sclerosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Antibodies to Epstein-Barr virus and neurotropic viruses in multiple sclerosis and optic neuritis

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  3. B cells from patients with multiple sclerosis have a pathogenic phenotype and increased LTα and TGFβ1 response

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Inflammatory markers of CHMP2B-mediated frontotemporal dementia

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Validation of suPAR turbidimetric assay on Cobas® (c502 and c702) and comparison to suPAR ELISA

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. MAIT cell subtypes in multiple sclerosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Early Intrathecal T Helper 17.1 Cell Activity in Huntington Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Disentangling white-matter damage from physiological fibre orientation dispersion in multiple sclerosis

    Research output: Contribution to journalJournal articleResearchpeer-review

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Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only sparsely described. In the present study, we found lower concentrations of the long chain PFAS perfluorooctane sulfonic acid (PFOS) in MS than in healthy controls (HC). In HC, we did not detect associations between PFOS concentrations and immune phenotypes. Analyzing the impact of known MS risk factors on cellular immune functions, we found that smoking and Epstein-Barr nuclear antigen 1 antibodies were associated with distinct circulating immune cell changes. In summary, current background PFAS exposure is not an important risk factor for MS.

Original languageEnglish
JournalJournal of Neuroimmunology
Volume330
Pages (from-to)90-95
Number of pages6
ISSN0165-5728
DOIs
Publication statusPublished - 15 May 2019

    Research areas

  • Adult, Alkanesulfonic Acids/blood, Cohort Studies, Cross-Sectional Studies, Female, Fluorocarbons/blood, Humans, Immunity, Cellular/drug effects, Male, Middle Aged, Multiple Sclerosis/blood, Risk Factors

ID: 58576743