Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation

Cecilie Ammitzbøll; Lars Börnsen; Eva Rosa Petersen; Annette Bang Oturai; Helle Bach Søndergaard; Philippe Grandjean; Finn Sellebjerg

doi:10.1016/j.jneuroim.2019.03.002

Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation

Cecilie Ammitzbøll, Lars Börnsen, Eva Rosa Petersen, Annette Bang Oturai, Helle Bach Søndergaard, Philippe Grandjean, Finn Sellebjerg

Department of Neurology

Abstract

Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only sparsely described. In the present study, we found lower concentrations of the long chain PFAS perfluorooctane sulfonic acid (PFOS) in MS than in healthy controls (HC). In HC, we did not detect associations between PFOS concentrations and immune phenotypes. Analyzing the impact of known MS risk factors on cellular immune functions, we found that smoking and Epstein-Barr nuclear antigen 1 antibodies were associated with distinct circulating immune cell changes. In summary, current background PFAS exposure is not an important risk factor for MS.

Original language	English
Journal	Journal of Neuroimmunology
Volume	330
Pages (from-to)	90-95
Number of pages	6
ISSN	0165-5728
DOIs	https://doi.org/10.1016/j.jneuroim.2019.03.002
Publication status	Published - 15 May 2019

Keywords

Adult
Alkanesulfonic Acids/blood
Cohort Studies
Cross-Sectional Studies
Female
Fluorocarbons/blood
Humans
Immunity, Cellular/drug effects
Male
Middle Aged
Multiple Sclerosis/blood
Risk Factors

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10.1016/j.jneuroim.2019.03.002

Cite this

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title = "Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation",

abstract = "Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only sparsely described. In the present study, we found lower concentrations of the long chain PFAS perfluorooctane sulfonic acid (PFOS) in MS than in healthy controls (HC). In HC, we did not detect associations between PFOS concentrations and immune phenotypes. Analyzing the impact of known MS risk factors on cellular immune functions, we found that smoking and Epstein-Barr nuclear antigen 1 antibodies were associated with distinct circulating immune cell changes. In summary, current background PFAS exposure is not an important risk factor for MS.",

keywords = "Adult, Alkanesulfonic Acids/blood, Cohort Studies, Cross-Sectional Studies, Female, Fluorocarbons/blood, Humans, Immunity, Cellular/drug effects, Male, Middle Aged, Multiple Sclerosis/blood, Risk Factors",

author = "Cecilie Ammitzb{\o}ll and Lars B{\"o}rnsen and Petersen, {Eva Rosa} and Oturai, {Annette Bang} and S{\o}ndergaard, {Helle Bach} and Philippe Grandjean and Finn Sellebjerg",

year = "2019",

month = may,

day = "15",

doi = "10.1016/j.jneuroim.2019.03.002",

language = "English",

volume = "330",

pages = "90--95",

journal = "Journal of Neuroimmunology",

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TY - JOUR

T1 - Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation

AU - Ammitzbøll, Cecilie

AU - Börnsen, Lars

AU - Petersen, Eva Rosa

AU - Oturai, Annette Bang

AU - Søndergaard, Helle Bach

AU - Grandjean, Philippe

AU - Sellebjerg, Finn

PY - 2019/5/15

Y1 - 2019/5/15

N2 - Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only sparsely described. In the present study, we found lower concentrations of the long chain PFAS perfluorooctane sulfonic acid (PFOS) in MS than in healthy controls (HC). In HC, we did not detect associations between PFOS concentrations and immune phenotypes. Analyzing the impact of known MS risk factors on cellular immune functions, we found that smoking and Epstein-Barr nuclear antigen 1 antibodies were associated with distinct circulating immune cell changes. In summary, current background PFAS exposure is not an important risk factor for MS.

AB - Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only sparsely described. In the present study, we found lower concentrations of the long chain PFAS perfluorooctane sulfonic acid (PFOS) in MS than in healthy controls (HC). In HC, we did not detect associations between PFOS concentrations and immune phenotypes. Analyzing the impact of known MS risk factors on cellular immune functions, we found that smoking and Epstein-Barr nuclear antigen 1 antibodies were associated with distinct circulating immune cell changes. In summary, current background PFAS exposure is not an important risk factor for MS.

KW - Adult

KW - Alkanesulfonic Acids/blood

KW - Cohort Studies

KW - Cross-Sectional Studies

KW - Female

KW - Fluorocarbons/blood

KW - Humans

KW - Immunity, Cellular/drug effects

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis/blood

KW - Risk Factors

U2 - 10.1016/j.jneuroim.2019.03.002

DO - 10.1016/j.jneuroim.2019.03.002

M3 - Journal article

C2 - 30852181

SN - 0165-5728

VL - 330

SP - 90

EP - 95

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation

Abstract

Keywords

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