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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Percutaneous left atrial appendage occlusion for stroke prevention in atrial fibrillation: an update

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  1. Associations between common ECG abnormalities and out-of-hospital cardiac arrest

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  2. Prevalence of early stages of heart failure in an elderly risk population: the Copenhagen Heart Failure Risk Study

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  3. Coronary risk stratification of patients with newly diagnosed heart failure

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  4. Echocardiographic subtypes of heart failure in consecutive hospitalised patients with dyspnoea

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  1. Diagnostic Potential of Intracardiac Echocardiography in Patients with Suspected Prosthetic Valve Endocarditis

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  2. Duration of Heart Failure and Effect of Defibrillator Implantation in Patients With Nonischemic Systolic Heart Failure

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  3. Mortality and morbidity of major congenital heart disease related to general prenatal screening for malformations

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Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia encountered in clinical practice. One of its most devastating complications is the development of thromboembolism leading to fatal or disabling stroke. Oral anticoagulation (OAC, warfarin) is the standard treatment for stroke prevention in patients with AF with an increased stroke risk. However, there are several obstacles to long-term OAC therapy, including the risk of serious bleeding, several drug-drug interactions and the need for frequent blood testing. Although newer oral anticoagulants have been developed, these drugs also face issues of major bleeding and non-compliance. Therefore, alternative treatment options for stroke prevention in patients with AF with a high stroke risk are needed. Percutaneous left atrial appendage (LAA) occlusion is an evolving therapy, which should be taken into consideration in those patients with non-valvular AF with a high stroke risk and contraindications for OAC. This article aims to discuss the rationale for LAA closure, the available LAA occlusion devices and their clinical evidence until now. Moreover, we discuss the importance of proper patient selection, the role of various imaging techniques and the need for a more tailored postprocedural antithrombotic therapy.

Original languageEnglish
JournalOpen Heart
Volume1
Issue number1
Pages (from-to)e000020
DOIs
Publication statusPublished - 2014

ID: 45028014