Abstract
Background: Peptidylglycine α-amidating mono-oxygenase (PAM) is an enzyme involved in the maturation of regulatory peptides. Here we examined PAM activity and adrenomedullin (bio-ADM) concentrations in patients with hepatic cirrhosis and determined net changes across the liver, kidneys and leg. Materials & methods: A total of 48 patients with hepatic cirrhosis and 16 control subjects were included. All patients and controls underwent an invasive procedure with blood collected across organs. Results: PAM activity was increased in cirrhotic patients but without a net change across the liver, leg or kidney. In contrast, bio-ADM concentrations were associated with severity of disease and found to be higher in venous blood from the liver. Conclusion: Increased PAM activity in patients with hepatic cirrhosis may reflect other organs involved in cirrhotic disease.
Original language | English |
---|---|
Journal | Biomarkers in Medicine |
Volume | 17 |
Issue number | 13 |
Pages (from-to) | 577-583 |
Number of pages | 7 |
ISSN | 2050-7771 |
DOIs | |
Publication status | Published - Oct 2023 |
Keywords
- Adrenomedullin
- Humans
- Liver Cirrhosis
- Mixed Function Oxygenases
- Multienzyme Complexes