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Peptide Hormones in the Gastrointestinal Tract

Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  1. Cholecystokinin and panic disorder: reflections on the history and some unsolved questions

    Research output: Contribution to journalReviewResearchpeer-review

  2. Liraglutide decreases postprandial fibroblast growth factor 19 and glucagon-like peptide 2, and increases postprandial cholecystokinin in individuals with obesity

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  3. Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy young men

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Expression of cholecystokinin and its receptors in the intestinal tract of type 2 diabetes patients and healthy controls

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Gastrin and the moderate hypergastrinemias

    Research output: Contribution to journalReviewResearchpeer-review

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Gastrointestinal hormones are peptides released from endocrine cells and neurons in the digestive tract. More than 30 hormone genes are currently known to be expressed in the gastrointestinal tract, which makes the gut the largest hormone-producing organ in the body. Modern biology makes it feasible to conceive the hormones under five headings. (1) The structural homology groups a majority of the hormones into nine families, each of which is assumed to originate from one ancestral gene. (2) The individual hormone gene often has multiple phenotypes due to alternative splicing, tandem organization, or differentiated maturation of the prohormone. By a combination of these mechanisms, more than 100 different hormonally active peptides are released from the gut. (3) Gut hormone genes are also widely expressed outside the gut, some only in extraintestinal endocrine cells and neurons but others also in other cell types. (4) The extraintestinal cells may express different bioactive fragments of the same prohormone due to cell-specific processing pathways. (5) Finally, endocrine cells, neurons, and, for instance, spermatozoa display differential release of gut peptides, so the same peptide may act as a blood-borne hormone, a neurotransmitter, a long-acting growth factor, or a fertility factor.
Original languageEnglish
Title of host publicationPeptide Hormones in the Gastrointestinal Tract
Publication date2015
Publication statusPublished - 2015

ID: 45861099