TY - JOUR
T1 - Pentraxin 3 in the cerebrospinal fluid during central nervous system infections
T2 - A retrospective cohort study
AU - Thomsen, Martin Munthe
AU - Munthe-Fog, Lea
AU - Trier Petersen, Pelle
AU - Hillig, Thore
AU - Friis-Hansen, Lennart Jan
AU - Roed, Casper
AU - Harboe, Zitta Barrella
AU - Brandt, Christian Thomas
N1 - Copyright: © 2023 Thomsen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2023
Y1 - 2023
N2 - The present study describes diagnostic and prognostic abilities of Cerebrospinal fluid (CSF) Pentraxin 3 (PTX3) in central nervous system (CNS) infections. CSF PTX3 was measured retrospectively from 174 patients admitted under suspicion of CNS infection. Medians, ROC curves and Youdens index was calculated. CSF PTX3 was significantly higher among all CNS infections and undetectable in most of the patients in the control group, and significantly higher in bacterial infections compared to viral and Lyme infections. No association was found between CSF PTX3 and Glasgow Outcome Score. PTX3 in the CSF can distinguish bacterial infection from viral and Lyme infections and non-CNS infections. Highest levels were found in bacterial meningitis. No prognostic abilities were found.
AB - The present study describes diagnostic and prognostic abilities of Cerebrospinal fluid (CSF) Pentraxin 3 (PTX3) in central nervous system (CNS) infections. CSF PTX3 was measured retrospectively from 174 patients admitted under suspicion of CNS infection. Medians, ROC curves and Youdens index was calculated. CSF PTX3 was significantly higher among all CNS infections and undetectable in most of the patients in the control group, and significantly higher in bacterial infections compared to viral and Lyme infections. No association was found between CSF PTX3 and Glasgow Outcome Score. PTX3 in the CSF can distinguish bacterial infection from viral and Lyme infections and non-CNS infections. Highest levels were found in bacterial meningitis. No prognostic abilities were found.
UR - http://www.scopus.com/inward/record.url?scp=85149335667&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0282004
DO - 10.1371/journal.pone.0282004
M3 - Journal article
C2 - 36862691
VL - 18
SP - e0282004
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 3
M1 - e0282004
ER -