Penetrance of hypertrophic cardiomyopathy in children and adolescents: a 12-year follow-up study of clinical screening and predictive genetic testing

Morten K Jensen; Ole Havndrup; Michael Christiansen; Paal S Andersen; Birgitte Diness; Anna Axelsson; Flemming Skovby; Lars Køber; Henning Bundgaard

doi:10.1161/CIRCULATIONAHA.111.090514

Penetrance of hypertrophic cardiomyopathy in children and adolescents: a 12-year follow-up study of clinical screening and predictive genetic testing

Morten K Jensen, Ole Havndrup, Michael Christiansen, Paal S Andersen, Birgitte Diness, Anna Axelsson, Flemming Skovby, Lars Køber, Henning Bundgaard

Department of Clinical Genetics

120 Citations (Scopus)

Abstract

The penetrance of hypertrophic cardiomyopathy (HCM) during childhood and adolescence has been only sparsely described. We studied the penetrance of HCM and the short- and long-term outcomes of clinical screening and predictive genetic testing of child relatives of patients with HCM.

Original language	English
Journal	Circulation (Baltimore)
Volume	127
Issue number	1
Pages (from-to)	48-54
Number of pages	7
ISSN	0009-7322
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.111.090514
Publication status	Published - 1 Jan 2013

Keywords

Adolescent
Adult
Age of Onset
Cardiomyopathy, Hypertrophic, Familial
Child
Echocardiography
Electrocardiography
Family
Follow-Up Studies
Genetic Predisposition to Disease
Genetic Testing
Heterozygote
Humans
Penetrance
Phenotype
Predictive Value of Tests
Risk Factors
Sarcomeres

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10.1161/CIRCULATIONAHA.111.090514

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Jensen, M. K., Havndrup, O., Christiansen, M., Andersen, P. S., Diness, B., Axelsson, A., Skovby, F., Køber, L., & Bundgaard, H. (2013). Penetrance of hypertrophic cardiomyopathy in children and adolescents: a 12-year follow-up study of clinical screening and predictive genetic testing. Circulation (Baltimore), 127(1), 48-54. https://doi.org/10.1161/CIRCULATIONAHA.111.090514

Penetrance of hypertrophic cardiomyopathy in children and adolescents: a 12-year follow-up study of clinical screening and predictive genetic testing. / Jensen, Morten K; Havndrup, Ole; Christiansen, Michael et al.
In: Circulation (Baltimore), Vol. 127, No. 1, 01.01.2013, p. 48-54.

Research output: Contribution to journal › Journal article › Research › peer-review

Jensen, MK, Havndrup, O, Christiansen, M, Andersen, PS, Diness, B , Axelsson, A, Skovby, F, Køber, L & Bundgaard, H 2013, 'Penetrance of hypertrophic cardiomyopathy in children and adolescents: a 12-year follow-up study of clinical screening and predictive genetic testing', Circulation (Baltimore), vol. 127, no. 1, pp. 48-54. https://doi.org/10.1161/CIRCULATIONAHA.111.090514

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AU - Andersen, Paal S

AU - Diness, Birgitte

AU - Axelsson, Anna

AU - Skovby, Flemming

AU - Køber, Lars

AU - Bundgaard, Henning

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KW - Adult

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KW - Echocardiography

KW - Electrocardiography

KW - Family

KW - Follow-Up Studies

KW - Genetic Predisposition to Disease

KW - Genetic Testing

KW - Heterozygote

KW - Humans

KW - Penetrance

KW - Phenotype

KW - Predictive Value of Tests

KW - Risk Factors

KW - Sarcomeres

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M3 - Journal article

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SN - 0009-7322

VL - 127

SP - 48

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JO - Circulation (Baltimore)

JF - Circulation (Baltimore)

IS - 1

ER -

Penetrance of hypertrophic cardiomyopathy in children and adolescents: a 12-year follow-up study of clinical screening and predictive genetic testing

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Keywords

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