Pediatric toxic epidermal necrolysis treated successfully with infliximab

Lana Chafranska; Ditte Marie Saunte; Nille Behrendt; Ulrikka Nygaard; Ryan J Christensen; Carsten Sand; Gregor B Jemec

doi:10.1111/pde.13778

Pediatric toxic epidermal necrolysis treated successfully with infliximab

Lana Chafranska, Ditte Marie Saunte, Nille Behrendt, Ulrikka Nygaard, Ryan J Christensen, Carsten Sand, Gregor B Jemec

Abstract

Successful management of toxic epidermal necrolysis (TEN) with tumor necrosis factor-α inhibitors has been described in adults. We present a case of a 7-year-old boy with infection-associated TEN, diagnosed by typical clinical and histopathological features, most likely caused by Mycoplasma pneumoniae. Treatment with a single dose of infliximab 5 mg/kg intravenously on day 5 after the onset of symptoms was followed by cessation of all blister formation over 3 days and complete resolution within a week. Sequelae were mild, consisting of postinflammatory hyperpigmentation and dry eyes.

Original language	English
Journal	Pediatric Dermatology
Volume	36
Issue number	3
Pages (from-to)	342-345
Number of pages	4
ISSN	0736-8046
DOIs	https://doi.org/10.1111/pde.13778
Publication status	Published - May 2019

Keywords

Child
Dermatologic Agents/therapeutic use
Humans
Infliximab/therapeutic use
Male
Mycoplasma pneumoniae/isolation & purification
Stevens-Johnson Syndrome/drug therapy

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10.1111/pde.13778

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title = "Pediatric toxic epidermal necrolysis treated successfully with infliximab",

abstract = "Successful management of toxic epidermal necrolysis (TEN) with tumor necrosis factor-α inhibitors has been described in adults. We present a case of a 7-year-old boy with infection-associated TEN, diagnosed by typical clinical and histopathological features, most likely caused by Mycoplasma pneumoniae. Treatment with a single dose of infliximab 5 mg/kg intravenously on day 5 after the onset of symptoms was followed by cessation of all blister formation over 3 days and complete resolution within a week. Sequelae were mild, consisting of postinflammatory hyperpigmentation and dry eyes.",

keywords = "Child, Dermatologic Agents/therapeutic use, Humans, Infliximab/therapeutic use, Male, Mycoplasma pneumoniae/isolation & purification, Stevens-Johnson Syndrome/drug therapy",

author = "Lana Chafranska and Saunte, {Ditte Marie} and Nille Behrendt and Ulrikka Nygaard and Christensen, {Ryan J} and Carsten Sand and Jemec, {Gregor B}",

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year = "2019",

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doi = "10.1111/pde.13778",

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volume = "36",

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T1 - Pediatric toxic epidermal necrolysis treated successfully with infliximab

AU - Chafranska, Lana

AU - Saunte, Ditte Marie

AU - Behrendt, Nille

AU - Nygaard, Ulrikka

AU - Christensen, Ryan J

AU - Sand, Carsten

AU - Jemec, Gregor B

PY - 2019/5

Y1 - 2019/5

N2 - Successful management of toxic epidermal necrolysis (TEN) with tumor necrosis factor-α inhibitors has been described in adults. We present a case of a 7-year-old boy with infection-associated TEN, diagnosed by typical clinical and histopathological features, most likely caused by Mycoplasma pneumoniae. Treatment with a single dose of infliximab 5 mg/kg intravenously on day 5 after the onset of symptoms was followed by cessation of all blister formation over 3 days and complete resolution within a week. Sequelae were mild, consisting of postinflammatory hyperpigmentation and dry eyes.

AB - Successful management of toxic epidermal necrolysis (TEN) with tumor necrosis factor-α inhibitors has been described in adults. We present a case of a 7-year-old boy with infection-associated TEN, diagnosed by typical clinical and histopathological features, most likely caused by Mycoplasma pneumoniae. Treatment with a single dose of infliximab 5 mg/kg intravenously on day 5 after the onset of symptoms was followed by cessation of all blister formation over 3 days and complete resolution within a week. Sequelae were mild, consisting of postinflammatory hyperpigmentation and dry eyes.

KW - Child

KW - Dermatologic Agents/therapeutic use

KW - Humans

KW - Infliximab/therapeutic use

KW - Male

KW - Mycoplasma pneumoniae/isolation & purification

KW - Stevens-Johnson Syndrome/drug therapy

U2 - 10.1111/pde.13778

DO - 10.1111/pde.13778

M3 - Journal article

C2 - 30834560

SN - 0736-8046

VL - 36

SP - 342

EP - 345

JO - Pediatric Dermatology

JF - Pediatric Dermatology

IS - 3

ER -

Pediatric toxic epidermal necrolysis treated successfully with infliximab

Abstract

Keywords

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