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Patterns of cerebral tissue oxygen tension and cytoplasmic redox state in bacterial meningitis

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Larsen, L, Nielsen, TH, Nordström, CH, Andersen, AB, Schierbeck, J, Schulz, MK & Poulsen, FR 2019, 'Patterns of cerebral tissue oxygen tension and cytoplasmic redox state in bacterial meningitis' Acta Anaesthesiologica Scandinavica, vol. 63, no. 3, pp. 329-36. https://doi.org/10.1111/aas.13278

APA

Larsen, L., Nielsen, T. H., Nordström, C. H., Andersen, A. B., Schierbeck, J., Schulz, M. K., & Poulsen, F. R. (2019). Patterns of cerebral tissue oxygen tension and cytoplasmic redox state in bacterial meningitis. Acta Anaesthesiologica Scandinavica, 63(3), 329-36. https://doi.org/10.1111/aas.13278

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Author

Larsen, Lykke ; Nielsen, Troels H. ; Nordström, Carl Henrik ; Andersen, Aase B. ; Schierbeck, Jens ; Schulz, Mette K. ; Poulsen, Frantz R. / Patterns of cerebral tissue oxygen tension and cytoplasmic redox state in bacterial meningitis. In: Acta Anaesthesiologica Scandinavica. 2019 ; Vol. 63, No. 3. pp. 329-36.

Bibtex

@article{625003f1bb514f10b10dac61e3c9f933,
title = "Patterns of cerebral tissue oxygen tension and cytoplasmic redox state in bacterial meningitis",
abstract = "BACKGROUND: Compromised cerebral energy metabolism is common in patients with bacterial meningitis. In this study, simultaneous measurements of cerebral oxygen tension and lactate/pyruvate ratio were compared to explore whether disturbed energy metabolism was usually caused by insufficient tissue oxygenation or compromised oxidative metabolism of pyruvate indicating mitochondrial dysfunction.SUBJECT AND METHODS: Ten consecutive patients with severe streptococcus meningitis were included in this prospective cohort study. Intracranial pressure, brain tissue oxygen tension (PbtO2 ), and energy metabolism (intracerebral microdialysis) were continuously monitored in nine patients. A cerebral lactate/pyruvate (LP) ratio <30 was considered indicating normal oxidative metabolism, LP ratio >30 simultaneously with pyruvate below lower normal level (70 µmol/L) was interpreted as biochemical indication of ischemia, and LP ratio >30 simultaneously with a normal or increased level of pyruvate was interpreted as mitochondrial dysfunction. The biochemical variables were compared with PbtO2 simultaneously monitored within the same cerebral region.RESULTS: In two cases, the LP ratio was normal during the whole study period and the simultaneously monitored PbtO2 was 18 ± 6 mm Hg. In six cases, interpreted as mitochondrial dysfunction, the simultaneously monitored PbtO2 was 20 ± 6 mm Hg and without correlation with the LP ratio. In one patient, exhibiting a pattern interpreted as ischemia, PbtO2 decreased below 10 mm Hg and a correlation between LP and PbtO2 was observed.CONCLUSION: This study demonstrated that compromised cerebral energy metabolism, evidenced by increased LP ratio, was common in patients with severe bacterial meningitis while not related to insufficient tissue oxygenation.",
keywords = "bacterial meningitis, cerebral tissue oxygenation, intracerebral microdialysis, intracranial pressure, ischemia, mitochondrial dysfunction",
author = "Lykke Larsen and Nielsen, {Troels H.} and Nordstr{\"o}m, {Carl Henrik} and Andersen, {Aase B.} and Jens Schierbeck and Schulz, {Mette K.} and Poulsen, {Frantz R.}",
note = "{\circledC} 2018 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.",
year = "2019",
month = "3",
day = "1",
doi = "10.1111/aas.13278",
language = "English",
volume = "63",
pages = "329--36",
journal = "Acta Anaesthesiologica Scandinavica",
issn = "0001-5172",
publisher = "Wiley-Blackwell Munksgaard",
number = "3",

}

RIS

TY - JOUR

T1 - Patterns of cerebral tissue oxygen tension and cytoplasmic redox state in bacterial meningitis

AU - Larsen, Lykke

AU - Nielsen, Troels H.

AU - Nordström, Carl Henrik

AU - Andersen, Aase B.

AU - Schierbeck, Jens

AU - Schulz, Mette K.

AU - Poulsen, Frantz R.

N1 - © 2018 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - BACKGROUND: Compromised cerebral energy metabolism is common in patients with bacterial meningitis. In this study, simultaneous measurements of cerebral oxygen tension and lactate/pyruvate ratio were compared to explore whether disturbed energy metabolism was usually caused by insufficient tissue oxygenation or compromised oxidative metabolism of pyruvate indicating mitochondrial dysfunction.SUBJECT AND METHODS: Ten consecutive patients with severe streptococcus meningitis were included in this prospective cohort study. Intracranial pressure, brain tissue oxygen tension (PbtO2 ), and energy metabolism (intracerebral microdialysis) were continuously monitored in nine patients. A cerebral lactate/pyruvate (LP) ratio <30 was considered indicating normal oxidative metabolism, LP ratio >30 simultaneously with pyruvate below lower normal level (70 µmol/L) was interpreted as biochemical indication of ischemia, and LP ratio >30 simultaneously with a normal or increased level of pyruvate was interpreted as mitochondrial dysfunction. The biochemical variables were compared with PbtO2 simultaneously monitored within the same cerebral region.RESULTS: In two cases, the LP ratio was normal during the whole study period and the simultaneously monitored PbtO2 was 18 ± 6 mm Hg. In six cases, interpreted as mitochondrial dysfunction, the simultaneously monitored PbtO2 was 20 ± 6 mm Hg and without correlation with the LP ratio. In one patient, exhibiting a pattern interpreted as ischemia, PbtO2 decreased below 10 mm Hg and a correlation between LP and PbtO2 was observed.CONCLUSION: This study demonstrated that compromised cerebral energy metabolism, evidenced by increased LP ratio, was common in patients with severe bacterial meningitis while not related to insufficient tissue oxygenation.

AB - BACKGROUND: Compromised cerebral energy metabolism is common in patients with bacterial meningitis. In this study, simultaneous measurements of cerebral oxygen tension and lactate/pyruvate ratio were compared to explore whether disturbed energy metabolism was usually caused by insufficient tissue oxygenation or compromised oxidative metabolism of pyruvate indicating mitochondrial dysfunction.SUBJECT AND METHODS: Ten consecutive patients with severe streptococcus meningitis were included in this prospective cohort study. Intracranial pressure, brain tissue oxygen tension (PbtO2 ), and energy metabolism (intracerebral microdialysis) were continuously monitored in nine patients. A cerebral lactate/pyruvate (LP) ratio <30 was considered indicating normal oxidative metabolism, LP ratio >30 simultaneously with pyruvate below lower normal level (70 µmol/L) was interpreted as biochemical indication of ischemia, and LP ratio >30 simultaneously with a normal or increased level of pyruvate was interpreted as mitochondrial dysfunction. The biochemical variables were compared with PbtO2 simultaneously monitored within the same cerebral region.RESULTS: In two cases, the LP ratio was normal during the whole study period and the simultaneously monitored PbtO2 was 18 ± 6 mm Hg. In six cases, interpreted as mitochondrial dysfunction, the simultaneously monitored PbtO2 was 20 ± 6 mm Hg and without correlation with the LP ratio. In one patient, exhibiting a pattern interpreted as ischemia, PbtO2 decreased below 10 mm Hg and a correlation between LP and PbtO2 was observed.CONCLUSION: This study demonstrated that compromised cerebral energy metabolism, evidenced by increased LP ratio, was common in patients with severe bacterial meningitis while not related to insufficient tissue oxygenation.

KW - bacterial meningitis

KW - cerebral tissue oxygenation

KW - intracerebral microdialysis

KW - intracranial pressure, ischemia

KW - mitochondrial dysfunction

UR - http://www.scopus.com/inward/record.url?scp=85055029376&partnerID=8YFLogxK

U2 - 10.1111/aas.13278

DO - 10.1111/aas.13278

M3 - Journal article

VL - 63

SP - 329

EP - 336

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

IS - 3

ER -

ID: 56393536