Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Effect of physical exercise on markers of neuronal dysfunction in cerebrospinal fluid in patients with Alzheimer's disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Hypozincaemia is associated with severity of aneurysmal subarachnoid haemorrhage: a retrospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Impact of glucose on risk of dementia: Mendelian randomisation studies in 115,875 individuals

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Type-2 diabetes and risk of dementia: observational and Mendelian randomisation studies in 1 million individuals

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Introduction: Our group has completed an exercise study of 200 patients with mild Alzheimer's disease. We found improvements in cognitive, neuropsychiatric, and physical measures in the participants who adhered to the protocol. Epidemiological studies in healthy elderly suggest that exercise preserves cognitive and physical abilities to a higher extent in APOE ε4 carriers.

Methods: In this post hoc subgroup analysis study, we investigated whether the beneficial effect of an exercise intervention in patients with mild AD was dependent on the patients' APOE genotype.

Results: We found that patients who were APOE ε4 carriers benefitted more from the exercise intervention by preservation of cognitive performance and improvement in physical measures.

Discussion: This exploratory study establishes a possible connection between the beneficial effects of exercise in AD and the patients' APOE genotype. These findings, if validated, could greatly impact the clinical management of patients with AD and those at risk for developing AD.

Original languageEnglish
JournalAlzheimer's & dementia (New York, N. Y.)
Volume5
Pages (from-to)99-106
Number of pages8
ISSN2352-8737
DOIs
Publication statusPublished - Jan 2019

ID: 58019954