Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Patient-Reported Outcomes and Medication Adherence in Patients with Heart Failure

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Protective association of angiotensin blockade with influenza: A result of immortal time bias?

    Research output: Contribution to journalLetterResearchpeer-review

  2. Assessing absolute stroke risk in patients with atrial fibrillation using a risk factor based approach

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Vitamin K antagonists vs. direct oral anticoagulants after transcatheter aortic valve implantation in atrial fibrillation

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Switching from Vitamin K Antagonist to Dabigatran in Atrial Fibrillation: Differences According to Dose

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prognostic Impact of Self-Reported Health on Clinical Outcomes in Patients with Heart Failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Am I going to die now? Experiences of hospitalisation and subsequent life after being diagnosed with aortic dissection

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. In the eye of the hurricane - a qualitative study on what is at stake for close family members to patients hospitalized with COVID-19

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

AIMS: Patient-reported outcome measures (PROMs) may predict poor clinical outcome in patients with heart failure (HF). It remains unclear whether PROMs are associated with subsequent adherence to HF medication. We aimed to determine whether health-related quality of life, anxiety, and depression were associated with long-term medication adherence in these patients.

METHODS AND RESULTS: A national cohort study of Danish patients with HF with 3-year follow-up (n = 1464). PROMs included the EuroQol five-dimensional, five-level questionnaire (EQ-5D-5L), the HeartQoL and the Hospital Anxiety and Depression Scale (HADS). Patient-reported outcomes (PRO) data were linked to demographic and clinical data at baseline, and data on all redeemed prescriptions for angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers/angiotensin receptor neprilysin inhibitors (ACEI/ARB/ARNI), β-blockers, and mineralocorticoid receptor antagonists during follow-up. Medication non-adherence was defined as <80% of proportion of days covered. In adjusted regression analyses, lower health-related quality of life (EQ-5D and HeartQoL) and symptoms of depression (HADS-D) at discharge were associated with non-adherence. After 3 years of follow-up, lower health-related quality of life (EQ-5D) was associated with non-adherence for ACEI/ARB/ARNI [adjusted OR 2.78, 95% confidence interval (CI): 1.19-6.49], β-blockers (adjusted OR 2.35, 95% CI: 1.04-5.29), whereas HADS-D was associated with non-adherence for ACEI/ARB/ARNI (adjusted OR 1.07, 95% CI: 1.03-1.11) and β-blockers (adjusted OR 1.06, 95% CI: 1.02-1.10).

CONCLUSION: Lower health-related quality of life and symptoms of depression were associated with non-adherence across HF medications at 1 and 3 years of follow-up. Person-centred care using PROMs may carry a potential for identifying patients at increased risk of future medication non-adherence.

Original languageEnglish
JournalEuropean heart journal. Cardiovascular pharmacotherapy
Volume7
Issue number4
Pages (from-to)287-295
Number of pages9
ISSN2055-6837
DOIs
Publication statusPublished - 1 Jul 2021

    Research areas

  • Heart failure, Medication adherence, Patient-reported outcomes

ID: 62329852