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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Patient self-testing of white blood cell count and differentiation: A study of feasibility and measurement performance in a population of Danish cancer patients

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OBJECTIVE: Patients in anticancer treatment with a known side effect of neutropenia are monitored closely with laboratory measurements of white blood cell count (WBC) and differentiation. This study sought to evaluate measurement properties and feasibility of patients' self-testing using a point-of-care testing (POCT) device.

METHODS: A prospective feasibility and measurement study comparing the standard measurement of cancer patients' WBC and neutrophil count with POCT measurements. The study included 60 outpatients and 22 inpatients from a department of oncology at a university hospital.

RESULTS: Patients successfully conducted 106 measurements using the POCT device. 46% of the patients were >70 years. Weighted Deming regression analysis showed minimal yet significant proportional bias between methods, with POCT increasingly underestimating both total WBC and neutrophils compared with the standard method the higher the count. Over 90% of patients reported they were willing and considered themselves able to use the POCT device at home.

CONCLUSIONS: The instrument can be used for self-testing of post-anticancer leukopenia and has sufficient measurement precision for patient risk stratification. Patients are able and willing to conduct measurements including when in a situation of acute illness. Further studies are needed to confirm safety and value within patients' own home.

Original languageEnglish
Article numbere13189
JournalEuropean Journal of Cancer Care
Volume29
Issue number1
ISSN0961-5423
DOIs
Publication statusPublished - 2020

Bibliographical note

Publisher Copyright:
© 2019 John Wiley & Sons Ltd

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

    Research areas

  • aged, antineoplastic agents, febrile neutropenia, medical oncology, patient comfort, patient education, point-of-care testing

ID: 59581088