Pathophysiology of acute mountain sickness and high altitude pulmonary oedema: an hypothesis

J R Sutton, N Lassen

46 Citations (Scopus)

Abstract

We review the evidence that acute mountain sickness (AMS) and high altitude pulmonary oedema (HAPO) occur together more often than is realized. We hypothesize that AMS and HAPO have a common pathophysiological basis: both are due to increased pressure and flow in the microcirculation, causing oedema in the brain and oedema in the lungs.
Original languageEnglish
JournalBulletin européen de physiopathologie respiratoire
Volume15
Issue number5
Pages (from-to)1045-52
Number of pages8
ISSN0395-3890
Publication statusPublished - 1979

Keywords

  • Altitude
  • Altitude Sickness
  • Anoxia
  • Brain
  • Brain Edema
  • Humans
  • Lung
  • Microcirculation
  • Pressure
  • Pulmonary Edema
  • Regional Blood Flow
  • Vasoconstriction
  • Vasodilation

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