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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Pathophysiological-based treatments of complications of cirrhosis

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  1. eHealth: Disease activity measures are related to the faecal gut microbiota in adult patients with ulcerative colitis

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  3. Treatment patterns for biologics in ulcerative colitis and Crohn's disease: a Danish Nationwide Register Study from 2003 to 2015

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  1. Poor Concordance Between Liver Stiffness and Noninvasive Fibrosis Scores in HIV Infection Without Viral Hepatitis

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  2. Nonalcoholic Fatty Liver Disease Impairs the Liver-Alpha Cell Axis Independent of Hepatic Inflammation and Fibrosis

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  3. Pituitary adenylate cyclase-activating peptide: Potential roles in the pathophysiology and complications of cirrhosis

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Detailed knowledge and understanding of the pathophysiological mechanisms and changes in hepatic and splanchnic function leading to the development of haemodynamic changes and portal hypertension in patients with cirrhosis are essential since it guides the search for targets to ameliorate liver-related abnormalities. Recent research has focused on the gut-liver axis, changes in intestinal permeability, translocation of bacterial products, and inflammation as important drivers of haemodynamic alterations and thereby targets for treatment. Additionally, treatment strategies should focus on microbiotic modulation, antiangiogenics, anti-inflammatory strategies, and modulation of bile acid metabolism. This paper aims to review contemporary pathophysiological-based treatment principles of the major complications of cirrhosis and portal hypertension and future targets for treatment.

Original languageEnglish
JournalScandinavian Journal of Gastroenterology
Volume55
Issue number4
Pages (from-to)383-394
Number of pages12
ISSN0036-5521
DOIs
Publication statusPublished - Apr 2020

    Research areas

  • ascites, hepatopulmonary syndrome, hepatorenal syndrome, hyperdynamic circulation, oesophageal varices, Portal hypertension

ID: 59656383