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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Pathophysiological-based treatments of complications of cirrhosis

Research output: Contribution to journalReviewResearchpeer-review

  1. Behandling af navlebrok hos patienter med cirrose

    Research output: Contribution to journalReviewResearchpeer-review

  2. Determination of hepatic clearance by derivations of the indocyanine green retention test in cirrhosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The impact of rifaximin on inflammation and metabolism in alcoholic hepatitis: A randomized clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Patients with cirrhosis have elevated bone turnover but normal hepatic production of osteoprotegerin

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Intranasal treatment of cluster headache: A response

    Research output: Contribution to journalLetterResearchpeer-review

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Detailed knowledge and understanding of the pathophysiological mechanisms and changes in hepatic and splanchnic function leading to the development of haemodynamic changes and portal hypertension in patients with cirrhosis are essential since it guides the search for targets to ameliorate liver-related abnormalities. Recent research has focused on the gut-liver axis, changes in intestinal permeability, translocation of bacterial products, and inflammation as important drivers of haemodynamic alterations and thereby targets for treatment. Additionally, treatment strategies should focus on microbiotic modulation, antiangiogenics, anti-inflammatory strategies, and modulation of bile acid metabolism. This paper aims to review contemporary pathophysiological-based treatment principles of the major complications of cirrhosis and portal hypertension and future targets for treatment.

Original languageEnglish
JournalScandinavian Journal of Gastroenterology
Volume55
Issue number4
Pages (from-to)383-394
Number of pages12
ISSN0036-5521
DOIs
Publication statusPublished - 2 Apr 2020

    Research areas

  • ascites, hepatopulmonary syndrome, hepatorenal syndrome, hyperdynamic circulation, oesophageal varices, Portal hypertension

ID: 59656383