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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Pathophysiological-based treatments of complications of cirrhosis

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  1. 3D analysis of the myenteric plexus of the human bowel by X-ray phase-contrast tomography - a future method?

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  2. Colonoscopy adverse events: are we getting the full picture?

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  3. True Chromogranin A concentrations in plasma from patients with small intestinal neuroendocrine tumours

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  1. The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology

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  2. Experience from a COVID-19 first-line referral clinic in Greater Copenhagen

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Detailed knowledge and understanding of the pathophysiological mechanisms and changes in hepatic and splanchnic function leading to the development of haemodynamic changes and portal hypertension in patients with cirrhosis are essential since it guides the search for targets to ameliorate liver-related abnormalities. Recent research has focused on the gut-liver axis, changes in intestinal permeability, translocation of bacterial products, and inflammation as important drivers of haemodynamic alterations and thereby targets for treatment. Additionally, treatment strategies should focus on microbiotic modulation, antiangiogenics, anti-inflammatory strategies, and modulation of bile acid metabolism. This paper aims to review contemporary pathophysiological-based treatment principles of the major complications of cirrhosis and portal hypertension and future targets for treatment.

Original languageEnglish
JournalScandinavian Journal of Gastroenterology
Volume55
Issue number4
Pages (from-to)383-394
Number of pages12
ISSN0036-5521
DOIs
Publication statusPublished - Apr 2020

    Research areas

  • ascites, hepatopulmonary syndrome, hepatorenal syndrome, hyperdynamic circulation, oesophageal varices, Portal hypertension

ID: 59656383