Pathological and therapeutic possibilities in inhibiting ocular angionesis

Yousif Subhi; Lasse Jørgensen Cehofski; Anders Højslet Vestergaard; Torben Lykke Sørensen; Jakob Grauslund

Pathological and therapeutic possibilities in inhibiting ocular angionesis

Translated title of the contribution: Pathological and therapeutic possibilities in inhibiting ocular angionesis

Yousif Subhi
, Lasse Jørgensen Cehofski
, Anders Højslet Vestergaard
, Torben Lykke Sørensen
, Jakob Grauslund

Abstract

In a variety of corneal and retinal diseases, ocular ischaemia mediates vascular endothelial growth factor (VEGF) expression, which in turn causes angiogenesis and increased vascular permeability. Consequently, VEGF-inhibitory treatment has been introduced in different ocular diseases. Hypoxia-inducible factor (HIF)-1α is an upstream regulator of VEGF-A, and increased HIF-1α expression has been established in ocular animal models. Upcoming translational studies are expected to increase our understanding of the complex balance between pro- and anti-angiogenic factors in the eye.

Translated title of the contribution	Pathological and therapeutic possibilities in inhibiting ocular angionesis
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	182
Issue number	44
ISSN	0041-5782
Publication status	Published - 26 Oct 2020
Externally published	Yes

Cite this

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title = "Pathological and therapeutic possibilities in inhibiting ocular angionesis",

abstract = "In a variety of corneal and retinal diseases, ocular ischaemia mediates vascular endothelial growth factor (VEGF) expression, which in turn causes angiogenesis and increased vascular permeability. Consequently, VEGF-inhibitory treatment has been introduced in different ocular diseases. Hypoxia-inducible factor (HIF)-1α is an upstream regulator of VEGF-A, and increased HIF-1α expression has been established in ocular animal models. Upcoming translational studies are expected to increase our understanding of the complex balance between pro- and anti-angiogenic factors in the eye.",

keywords = "Angiogenesis Inducing Agents, Animals, Vascular Endothelial Growth Factor A",

author = "Yousif Subhi and Cehofski, \{Lasse J{\o}rgensen\} and Vestergaard, \{Anders H{\o}jslet\} and S{\o}rensen, \{Torben Lykke\} and Jakob Grauslund",

year = "2020",

month = oct,

day = "26",

language = "Dansk",

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journal = "Ugeskrift for Laeger",

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TY - JOUR

T1 - Pathological and therapeutic possibilities in inhibiting ocular angionesis

AU - Subhi, Yousif

AU - Cehofski, Lasse Jørgensen

AU - Vestergaard, Anders Højslet

AU - Sørensen, Torben Lykke

AU - Grauslund, Jakob

PY - 2020/10/26

Y1 - 2020/10/26

N2 - In a variety of corneal and retinal diseases, ocular ischaemia mediates vascular endothelial growth factor (VEGF) expression, which in turn causes angiogenesis and increased vascular permeability. Consequently, VEGF-inhibitory treatment has been introduced in different ocular diseases. Hypoxia-inducible factor (HIF)-1α is an upstream regulator of VEGF-A, and increased HIF-1α expression has been established in ocular animal models. Upcoming translational studies are expected to increase our understanding of the complex balance between pro- and anti-angiogenic factors in the eye.

AB - In a variety of corneal and retinal diseases, ocular ischaemia mediates vascular endothelial growth factor (VEGF) expression, which in turn causes angiogenesis and increased vascular permeability. Consequently, VEGF-inhibitory treatment has been introduced in different ocular diseases. Hypoxia-inducible factor (HIF)-1α is an upstream regulator of VEGF-A, and increased HIF-1α expression has been established in ocular animal models. Upcoming translational studies are expected to increase our understanding of the complex balance between pro- and anti-angiogenic factors in the eye.

KW - Angiogenesis Inducing Agents

KW - Animals

KW - Vascular Endothelial Growth Factor A

M3 - Tidsskriftartikel

C2 - 33118489

SN - 0041-5782

VL - 182

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 44

ER -

Pathological and therapeutic possibilities in inhibiting ocular angionesis

Abstract

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