TY - JOUR
T1 - Paternal prescription medication before conception
T2 - A retrospective cohort study of all births in Denmark 1997-2017
AU - Wensink, M J
AU - Rizzi, S
AU - Jensen, T K
AU - Skakkebaek, N E
AU - Lu, Y
AU - Lindahl-Jacobsen, R
AU - Eisenberg, M L
PY - 2021/12
Y1 - 2021/12
N2 - AIM: To study what medication fathers are being prescribed in the months preceding conception.METHODS: A retrospective cohort study of Danish national registries, comprising all births in Denmark 1997-2017 (1.3 million births). Time trends and absolute levels of paternal prescription medication in the 6 months prior to conception were assessed. While all medications were examined (N = 1335), we focused on the main medication groups, medications that have increased in use over time, and medications for which previous evidence exists of an effect on sperm quality.RESULTS: The average number of prescriptions increased over the study period (from 0.75 prescriptions to 0.82 per birth). Polypharmacy (three or more prescriptions) increased from less than 8% to 10% of fathers. The use of pain medication, proton-pump inhibitors, selective serotonin reuptake inhibitors and some inhalants have all increased markedly over the last 20 years.CONCLUSIONS: Potential harm to the offspring done by paternal medication may present an increasing problem. As paternal medication exposure is increasing, examination of generational effects, such as major birth defects, is necessary.
AB - AIM: To study what medication fathers are being prescribed in the months preceding conception.METHODS: A retrospective cohort study of Danish national registries, comprising all births in Denmark 1997-2017 (1.3 million births). Time trends and absolute levels of paternal prescription medication in the 6 months prior to conception were assessed. While all medications were examined (N = 1335), we focused on the main medication groups, medications that have increased in use over time, and medications for which previous evidence exists of an effect on sperm quality.RESULTS: The average number of prescriptions increased over the study period (from 0.75 prescriptions to 0.82 per birth). Polypharmacy (three or more prescriptions) increased from less than 8% to 10% of fathers. The use of pain medication, proton-pump inhibitors, selective serotonin reuptake inhibitors and some inhalants have all increased markedly over the last 20 years.CONCLUSIONS: Potential harm to the offspring done by paternal medication may present an increasing problem. As paternal medication exposure is increasing, examination of generational effects, such as major birth defects, is necessary.
KW - Denmark/epidemiology
KW - Fathers
KW - Humans
KW - Male
KW - Paternal Exposure/adverse effects
KW - Prescriptions
KW - Retrospective Studies
UR - http://www.scopus.com/inward/record.url?scp=85101251674&partnerID=8YFLogxK
U2 - 10.1177/1403494820987468
DO - 10.1177/1403494820987468
M3 - Journal article
C2 - 33615897
SN - 1403-4956
VL - 49
SP - 884
EP - 890
JO - Scandinavian Journal of Public Health. Supplement
JF - Scandinavian Journal of Public Health. Supplement
IS - 8
ER -