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The Capital Region of Denmark - a part of Copenhagen University Hospital

Paternal prescription medication before conception: A retrospective cohort study of all births in Denmark 1997-2017

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AIM: To study what medication fathers are being prescribed in the months preceding conception.

METHODS: A retrospective cohort study of Danish national registries, comprising all births in Denmark 1997-2017 (1.3 million births). Time trends and absolute levels of paternal prescription medication in the 6 months prior to conception were assessed. While all medications were examined (N = 1335), we focused on the main medication groups, medications that have increased in use over time, and medications for which previous evidence exists of an effect on sperm quality.

RESULTS: The average number of prescriptions increased over the study period (from 0.75 prescriptions to 0.82 per birth). Polypharmacy (three or more prescriptions) increased from less than 8% to 10% of fathers. The use of pain medication, proton-pump inhibitors, selective serotonin reuptake inhibitors and some inhalants have all increased markedly over the last 20 years.

CONCLUSIONS: Potential harm to the offspring done by paternal medication may present an increasing problem. As paternal medication exposure is increasing, examination of generational effects, such as major birth defects, is necessary.

Original languageEnglish
Book seriesScandinavian Journal of Public Health. Supplement
Issue number8
Pages (from-to)884-890
Number of pages7
Publication statusPublished - Dec 2021

    Research areas

  • Denmark/epidemiology, Fathers, Humans, Male, Paternal Exposure/adverse effects, Prescriptions, Retrospective Studies

ID: 72896282