Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Paroxetine blunts the corticosterone response to swim-induced stress and increases depressive-like behavior in a rat model of postpartum depression

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Characteristics influencing expected cognitive performance during hypoglycaemia in type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Neuroticism modulates mood responses to pharmacological sex hormone manipulation in healthy women

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Multiple measures of HPA axis function in ultra high risk and first-episode schizophrenia patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Optimization of preprocessing strategies in Positron Emission Tomography (PET) neuroimaging: A [11C]DASB PET study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Evidence for oestrogen sensitivity in perinatal depression: pharmacological sex hormone manipulation study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Genome-wide gene expression in a pharmacological hormonal transition model and its relation to depressive symptoms

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Three weeks of SSRI administration enhances the visual perceptual threshold - a randomized placebo-controlled study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Perinatal depression (PND) affects 15% of women. During the perinatal period both stress- and gonadal hormones fluctuate widely. Putatively, these fluctuations are involved in PND disease mechanisms. The serotonin system is sensitive to such hormone fluctuations, and serotonin reuptake inhibitors (SSRIs) are used to treat PND, although treatment is suboptimal and it is not known at which peripartum time-point SSRI treatment may be most efficacious. In this study, we investigate the effect of the SSRI paroxetine (5mg/kgs.c.) on swim stress-induced corticosterone in a rat model of postpartum depression. In the rat model corticosterone (CORT; 40mg/kgs.c.) was administered in Sprague Dawley rats across postpartum day (PD)2 to PD14. Stress response was measured during the first exposure to the forced swim test (FST1), and depressive-like behavior was measured in both FST1 and FST2. We found that paroxetine completely blunted the swim stress-induced CORT response and increased depressive-like behavior in both FST1 and FST2. Our findings suggest that in the postpartum context, SSRIs compromise stress axis dynamics, which are needed for a healthy stress response. This is likely unfavorable for reversing depressive-like behavior and may provide a rationale for augmentation strategies beyond SSRIs alone to optimize the clinical management of PND.

Original languageEnglish
JournalPsychoneuroendocrinology
Volume89
Pages (from-to)223-228
Number of pages6
ISSN0306-4530
DOIs
Publication statusPublished - Mar 2018

    Research areas

  • Journal Article

ID: 53655834