Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Cerebrovascular effects of glibenclamide investigated using high-resolution magnetic resonance imaging in healthy volunteers

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Glutamate levels and perfusion in pons during migraine attacks: A 3T MRI study using proton spectroscopy and arterial spin labeling

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. High spatiotemporal vessel-specific hemodynamic mapping with multi-echo single-vessel fMRI

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Modification of oxygen consumption and blood flow in mouse somatosensory cortex by cell-type-specific neuronal activity

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Challenges in conducting paediatric trials with off-patent drugs

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. MR-vejledt laserablation til behandling af hjernetumorer og epilepsi

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Prevalence of cognitive impairment and its relation to mental health in Danish lymphoma survivors

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. A high-resolution in vivo atlas of the human brain's benzodiazepine binding site of GABAA receptors

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Patients with Parkinson's disease (PD) often suffer from non-motor symptoms, which may be caused by serotonergic dysfunction. Apart from alleviating the motor symptoms, Deep Brain Stimulation (DBS) in the subthalamic nucleus (STN) may also influence non-motor symptoms. The aim of this study is to investigate how turning DBS off affects the serotonergic system. We here exploit a novel functional PET neuroimaging methodology to evaluate the preservation of serotonergic neurons and capacity to release serotonin. We measured cerebral 5-HT1BR binding in 13 DBS-STN treated PD patients, at baseline and after turning DBS off. Ten age-matched volunteers served as controls. Clinical measures of motor symptoms were assessed under the two conditions and correlated to the PET measures of the static and dynamic integrity of the serotonergic system. PD patients exhibited a significant loss of frontal and parietal 5-HT1BR, and the loss was significantly correlated to motor symptom severity. We saw a corresponding release of serotonin, but only in brain regions with preserved 5-HT1BR, suggesting the presence of a presynaptic serotonergic deficit. Our study demonstrates that DBS-STN dynamically regulates the serotonin system in PD, and that preservation of serotonergic functions may be predictive of DBS-STN effects.

Original languageEnglish
JournalJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Pages (from-to)271678X20982389
ISSN0271-678X
DOIs
Publication statusE-pub ahead of print - 18 Jan 2021

    Research areas

  • Deep brain stimulation, Parkinson’s disease, positron emission tomography, serotonin (5-HT), symptoms

ID: 62238644