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Parental smoking and risk of childhood-onset type 1 diabetes

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Harvard

Magnus, MC, Tapia, G, Olsen, SF, Granstrom, C, Mårild, K, Ueland, PM, Midttun, Ø, Svensson, J, Johannesen, J, Skrivarhaug, T, Joner, G, Njølstad, PR, Størdal, K & Stene, LC 2018, 'Parental smoking and risk of childhood-onset type 1 diabetes' Epidemiology (Cambridge, Mass.), vol. 29, no. 6, pp. 848-856. https://doi.org/10.1097/EDE.0000000000000911

APA

Magnus, M. C., Tapia, G., Olsen, S. F., Granstrom, C., Mårild, K., Ueland, P. M., ... Stene, L. C. (2018). Parental smoking and risk of childhood-onset type 1 diabetes. Epidemiology (Cambridge, Mass.), 29(6), 848-856. https://doi.org/10.1097/EDE.0000000000000911

CBE

Magnus MC, Tapia G, Olsen SF, Granstrom C, Mårild K, Ueland PM, Midttun Ø, Svensson J, Johannesen J, Skrivarhaug T, Joner G, Njølstad PR, Størdal K, Stene LC. 2018. Parental smoking and risk of childhood-onset type 1 diabetes. Epidemiology (Cambridge, Mass.). 29(6):848-856. https://doi.org/10.1097/EDE.0000000000000911

MLA

Vancouver

Magnus MC, Tapia G, Olsen SF, Granstrom C, Mårild K, Ueland PM et al. Parental smoking and risk of childhood-onset type 1 diabetes. Epidemiology (Cambridge, Mass.). 2018 Nov;29(6):848-856. https://doi.org/10.1097/EDE.0000000000000911

Author

Magnus, Maria C ; Tapia, German ; Olsen, Sjurdur F ; Granstrom, Charlotta ; Mårild, Karl ; Ueland, Per M ; Midttun, Øivind ; Svensson, Jannet ; Johannesen, Jesper ; Skrivarhaug, Torild ; Joner, Geir ; Njølstad, Pål R ; Størdal, Ketil ; Stene, Lars C. / Parental smoking and risk of childhood-onset type 1 diabetes. In: Epidemiology (Cambridge, Mass.). 2018 ; Vol. 29, No. 6. pp. 848-856.

Bibtex

@article{bcf7b877cbc84a2ca46b6e05143fdf53,
title = "Parental smoking and risk of childhood-onset type 1 diabetes",
abstract = "BACKGROUND: A few prospective studies suggest an association between maternal smoking during pregnancy and lower risk of type 1 diabetes. However, the role of unmeasured confounding and misclassification remains unclear.METHODS: We comprehensively evaluated whether maternal smoking in pregnancy predicts lower risk of childhood-onset type 1 diabetes in two Scandinavian pregnancy cohorts (185,076 children; 689 cases) and a Norwegian register-based cohort (434,627 children; 692 cases). We measured cord blood cotinine as an objective marker of nicotine exposure during late pregnancy in 154 cases and 476 controls. We also examined paternal smoking during pregnancy, in addition to environmental tobacco smoke exposure the first 6 months of life, to clarify the role of characteristics of smokers in general.RESULTS: In the pregnancy cohorts, maternal smoking beyond gestational week 12 was inversely associated with type 1 diabetes, pooled adjusted Hazard Ratio (aHR) 0.66 (95{\%} CI: 0.51, 0.85). Similarly, in the Norwegian register-based cohort, children of mothers who still smoked at the end of pregnancy had lower risk of type 1 diabetes, aHR 0.65 (95{\%} CI: 0.47, 0.89). Cord blood cotinine ≥30 nmol/L was also associated with reduced risk of type 1 diabetes, adjusted Odd Ratio 0.42 (95{\%} CI: 0.17, 1.0). We observed no associations of paternal smoking during pregnancy, or environmental tobacco smoke exposure, with childhood-onset type 1 diabetes.CONCLUSION: Maternal sustained smoking during pregnancy is associated with lower risk of type 1 diabetes in children. This sheds new light on the potential intrauterine environmental origins of the disease.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",
author = "Magnus, {Maria C} and German Tapia and Olsen, {Sjurdur F} and Charlotta Granstrom and Karl M{\aa}rild and Ueland, {Per M} and {\O}ivind Midttun and Jannet Svensson and Jesper Johannesen and Torild Skrivarhaug and Geir Joner and Nj{\o}lstad, {P{\aa}l R} and Ketil St{\o}rdal and Stene, {Lars C}",
year = "2018",
month = "11",
doi = "10.1097/EDE.0000000000000911",
language = "English",
volume = "29",
pages = "848--856",
journal = "Epidemiology",
issn = "1044-3983",
publisher = "Lippincott Williams & Wilkins",
number = "6",

}

RIS

TY - JOUR

T1 - Parental smoking and risk of childhood-onset type 1 diabetes

AU - Magnus, Maria C

AU - Tapia, German

AU - Olsen, Sjurdur F

AU - Granstrom, Charlotta

AU - Mårild, Karl

AU - Ueland, Per M

AU - Midttun, Øivind

AU - Svensson, Jannet

AU - Johannesen, Jesper

AU - Skrivarhaug, Torild

AU - Joner, Geir

AU - Njølstad, Pål R

AU - Størdal, Ketil

AU - Stene, Lars C

PY - 2018/11

Y1 - 2018/11

N2 - BACKGROUND: A few prospective studies suggest an association between maternal smoking during pregnancy and lower risk of type 1 diabetes. However, the role of unmeasured confounding and misclassification remains unclear.METHODS: We comprehensively evaluated whether maternal smoking in pregnancy predicts lower risk of childhood-onset type 1 diabetes in two Scandinavian pregnancy cohorts (185,076 children; 689 cases) and a Norwegian register-based cohort (434,627 children; 692 cases). We measured cord blood cotinine as an objective marker of nicotine exposure during late pregnancy in 154 cases and 476 controls. We also examined paternal smoking during pregnancy, in addition to environmental tobacco smoke exposure the first 6 months of life, to clarify the role of characteristics of smokers in general.RESULTS: In the pregnancy cohorts, maternal smoking beyond gestational week 12 was inversely associated with type 1 diabetes, pooled adjusted Hazard Ratio (aHR) 0.66 (95% CI: 0.51, 0.85). Similarly, in the Norwegian register-based cohort, children of mothers who still smoked at the end of pregnancy had lower risk of type 1 diabetes, aHR 0.65 (95% CI: 0.47, 0.89). Cord blood cotinine ≥30 nmol/L was also associated with reduced risk of type 1 diabetes, adjusted Odd Ratio 0.42 (95% CI: 0.17, 1.0). We observed no associations of paternal smoking during pregnancy, or environmental tobacco smoke exposure, with childhood-onset type 1 diabetes.CONCLUSION: Maternal sustained smoking during pregnancy is associated with lower risk of type 1 diabetes in children. This sheds new light on the potential intrauterine environmental origins of the disease.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

AB - BACKGROUND: A few prospective studies suggest an association between maternal smoking during pregnancy and lower risk of type 1 diabetes. However, the role of unmeasured confounding and misclassification remains unclear.METHODS: We comprehensively evaluated whether maternal smoking in pregnancy predicts lower risk of childhood-onset type 1 diabetes in two Scandinavian pregnancy cohorts (185,076 children; 689 cases) and a Norwegian register-based cohort (434,627 children; 692 cases). We measured cord blood cotinine as an objective marker of nicotine exposure during late pregnancy in 154 cases and 476 controls. We also examined paternal smoking during pregnancy, in addition to environmental tobacco smoke exposure the first 6 months of life, to clarify the role of characteristics of smokers in general.RESULTS: In the pregnancy cohorts, maternal smoking beyond gestational week 12 was inversely associated with type 1 diabetes, pooled adjusted Hazard Ratio (aHR) 0.66 (95% CI: 0.51, 0.85). Similarly, in the Norwegian register-based cohort, children of mothers who still smoked at the end of pregnancy had lower risk of type 1 diabetes, aHR 0.65 (95% CI: 0.47, 0.89). Cord blood cotinine ≥30 nmol/L was also associated with reduced risk of type 1 diabetes, adjusted Odd Ratio 0.42 (95% CI: 0.17, 1.0). We observed no associations of paternal smoking during pregnancy, or environmental tobacco smoke exposure, with childhood-onset type 1 diabetes.CONCLUSION: Maternal sustained smoking during pregnancy is associated with lower risk of type 1 diabetes in children. This sheds new light on the potential intrauterine environmental origins of the disease.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

U2 - 10.1097/EDE.0000000000000911

DO - 10.1097/EDE.0000000000000911

M3 - Journal article

VL - 29

SP - 848

EP - 856

JO - Epidemiology

JF - Epidemiology

SN - 1044-3983

IS - 6

ER -

ID: 55230188