Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark)

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Sedentary work and risk of venous thromboembolism

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The influence of multiple occupational exposures on absence from work in pregnancy: a prospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Night work and postpartum depression: a national register-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Systematic literature review on the effects of occupational safety and health (OSH) interventions at the workplace

    Research output: Contribution to journalReviewResearchpeer-review

  1. Use of stored serum in the study of time trends and geographical differences in exposure of pregnant women to phthalates

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Bone mineral density is preserved in men with idiopathic infertility

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. CENTRAL PRECOCIOUS PUBERTY IN TWO BOYS WITH PRADER-WILLI SYNDROME ON GROWTH HORMONE TREATMENT

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Author Correction: Characterisation and localisation of the endocannabinoid system components in the adult human testis

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Ann Olsson
  • Kayo Togawa
  • Joachim Schüz
  • Charlotte Le Cornet
  • Beatrice Fervers
  • Susanne Oksbjerg Dalton
  • Eero Pukkala
  • Maria Feychting Maria Feychting
  • Niels Erik Skakkebæk
  • Johnni Hansen
View graph of relations

Objective The present study aims to assess if parental occupational exposure to solvents or heavy metals is associated with risk of testicular germ cell tumors (TGCT) in sons in Denmark. Methods The NORD-TEST Denmark included 3421 cases diagnosed with TGCT at ages 14-49 years in Denmark between 1981 and 2014. Controls (N=14 024) selected from the central population registry were matched to cases on birth year. The Danish Supplementary Pension Fund provided parental occupational information. A job-exposure matrix was used to assign exposures, and conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results The overall analyses showed no significant associations except for paternal exposure to a sub-group of "heavy metal(s) and solvent(s)" (OR 1.50, 95% CI 1.01-2.24). Most fathers in this category had worked in wood related jobs and were assigned exposure to chromium VI and toluene. Other sub-group analyses suggested that maternal exposure to aromatic hydrocarbon were associated with TGCT risk, in sons born in 1970-1979, and to heavy metals (chromium, iron and nickel) in sons born in 1980-1998. Conclusion NORD-TEST Denmark provides no strong support for an association between parental exposures to solvents or heavy metals and TGCT in sons, and only weak support for an association between paternal exposure to chromium and toluene and TGCT risk in sons.

Original languageEnglish
JournalScandinavian Journal of Work, Environment & Health
Volume44
Issue number6
Pages (from-to)658-669
Number of pages12
ISSN0355-3140
DOIs
Publication statusPublished - 1 Nov 2018

ID: 55611755