Pancreatic somatostatinoma. Clinical features and physiological implications

L I Larsson; M A Hirsch; J J Holst; S Ingemansson; C Kühl; S L Jensen; G Lundqvist; J F Rehfeld; T W Schwartz

doi:10.1016/s0140-6736(77)92113-4

Pancreatic somatostatinoma. Clinical features and physiological implications

L I Larsson
, M A Hirsch
, J J Holst
, S Ingemansson
, C Kühl
, S L Jensen
, G Lundqvist
, J F Rehfeld
, T W Schwartz

265 Citations (Scopus)

Abstract

The first case of a tumour producing somatostatin-like immunoreactivity and bioactivity is presented. The pancreatic tumour was composed of cells indistinguishable from islet D cells. Radioimmunoassay of blood-samples obtained by tumour-vein catheterisation revealed very high levels of somatostatin immunoreactivity. On gel chromatography tumour extracts were found to contain at least 4 different immunoreactive components, one of which eluted in the position of synthetic somatostatin. Extracts from the tumour were potent in inhibiting insulin and glucagon secretion from isolated perfused porcine pancreas. Clinical abnormalities included hypochlorhydria, steatorrhoea, and diabetic glucose tolerance. Conceivably some of these abnormalities may be related to somatostatin hypersecretion from the pancreatic tumour.

Original language	English
Journal	Lancet
Volume	1
Issue number	8013
Pages (from-to)	666-8
Number of pages	3
ISSN	0140-6736
DOIs	https://doi.org/10.1016/s0140-6736(77)92113-4
Publication status	Published - 26 Mar 1977
Externally published	Yes

Keywords

Antigen-Antibody Reactions
Chromatography, Gel
Female
Glucagon/antagonists & inhibitors
Hormones, Ectopic/metabolism
Humans
Insulin Antagonists
Islets of Langerhans/ultrastructure
Microscopy, Electron
Middle Aged
Pancreatic Neoplasms/metabolism
Somatostatin/immunology
Staining and Labeling/methods
Tissue Extracts/analysis

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10.1016/s0140-6736(77)92113-4

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title = "Pancreatic somatostatinoma. Clinical features and physiological implications",

abstract = "The first case of a tumour producing somatostatin-like immunoreactivity and bioactivity is presented. The pancreatic tumour was composed of cells indistinguishable from islet D cells. Radioimmunoassay of blood-samples obtained by tumour-vein catheterisation revealed very high levels of somatostatin immunoreactivity. On gel chromatography tumour extracts were found to contain at least 4 different immunoreactive components, one of which eluted in the position of synthetic somatostatin. Extracts from the tumour were potent in inhibiting insulin and glucagon secretion from isolated perfused porcine pancreas. Clinical abnormalities included hypochlorhydria, steatorrhoea, and diabetic glucose tolerance. Conceivably some of these abnormalities may be related to somatostatin hypersecretion from the pancreatic tumour.",

keywords = "Antigen-Antibody Reactions, Chromatography, Gel, Female, Glucagon/antagonists \& inhibitors, Hormones, Ectopic/metabolism, Humans, Insulin Antagonists, Islets of Langerhans/ultrastructure, Microscopy, Electron, Middle Aged, Pancreatic Neoplasms/metabolism, Somatostatin/immunology, Staining and Labeling/methods, Tissue Extracts/analysis",

author = "Larsson, \{L I\} and Hirsch, \{M A\} and Holst, \{J J\} and S Ingemansson and C K{\"u}hl and Jensen, \{S L\} and G Lundqvist and Rehfeld, \{J F\} and Schwartz, \{T W\}",

year = "1977",

month = mar,

day = "26",

doi = "10.1016/s0140-6736(77)92113-4",

language = "English",

volume = "1",

pages = "666--8",

journal = "Lancet",

issn = "0140-6736",

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number = "8013",

}

TY - JOUR

T1 - Pancreatic somatostatinoma. Clinical features and physiological implications

AU - Larsson, L I

AU - Hirsch, M A

AU - Holst, J J

AU - Ingemansson, S

AU - Kühl, C

AU - Jensen, S L

AU - Lundqvist, G

AU - Rehfeld, J F

AU - Schwartz, T W

PY - 1977/3/26

Y1 - 1977/3/26

N2 - The first case of a tumour producing somatostatin-like immunoreactivity and bioactivity is presented. The pancreatic tumour was composed of cells indistinguishable from islet D cells. Radioimmunoassay of blood-samples obtained by tumour-vein catheterisation revealed very high levels of somatostatin immunoreactivity. On gel chromatography tumour extracts were found to contain at least 4 different immunoreactive components, one of which eluted in the position of synthetic somatostatin. Extracts from the tumour were potent in inhibiting insulin and glucagon secretion from isolated perfused porcine pancreas. Clinical abnormalities included hypochlorhydria, steatorrhoea, and diabetic glucose tolerance. Conceivably some of these abnormalities may be related to somatostatin hypersecretion from the pancreatic tumour.

AB - The first case of a tumour producing somatostatin-like immunoreactivity and bioactivity is presented. The pancreatic tumour was composed of cells indistinguishable from islet D cells. Radioimmunoassay of blood-samples obtained by tumour-vein catheterisation revealed very high levels of somatostatin immunoreactivity. On gel chromatography tumour extracts were found to contain at least 4 different immunoreactive components, one of which eluted in the position of synthetic somatostatin. Extracts from the tumour were potent in inhibiting insulin and glucagon secretion from isolated perfused porcine pancreas. Clinical abnormalities included hypochlorhydria, steatorrhoea, and diabetic glucose tolerance. Conceivably some of these abnormalities may be related to somatostatin hypersecretion from the pancreatic tumour.

KW - Antigen-Antibody Reactions

KW - Chromatography, Gel

KW - Female

KW - Glucagon/antagonists & inhibitors

KW - Hormones, Ectopic/metabolism

KW - Humans

KW - Insulin Antagonists

KW - Islets of Langerhans/ultrastructure

KW - Microscopy, Electron

KW - Middle Aged

KW - Pancreatic Neoplasms/metabolism

KW - Somatostatin/immunology

KW - Staining and Labeling/methods

KW - Tissue Extracts/analysis

U2 - 10.1016/s0140-6736(77)92113-4

DO - 10.1016/s0140-6736(77)92113-4

M3 - Journal article

C2 - 66472

SN - 0140-6736

VL - 1

SP - 666

EP - 668

JO - Lancet

JF - Lancet

IS - 8013

ER -

Pancreatic somatostatinoma. Clinical features and physiological implications

Abstract

Keywords

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