Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy

Maria Siopi; Antonios Papadopoulos; Anastasia Spiliopoulou; Fotini Paliogianni; Nissrine Abou-Chakra; Maiken Cavling Arendrup; Christina Damoulari; Georgios Tsioulos; Efthymia Giannitsioti; Frantzeska Frantzeskaki; Iraklis Tsangaris; Spyros Pournaras; Joseph Meletiadis

doi:10.3390/jof8090931

Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy

Maria Siopi, Antonios Papadopoulos, Anastasia Spiliopoulou, Fotini Paliogianni, Nissrine Abou-Chakra, Maiken Cavling Arendrup, Christina Damoulari, Georgios Tsioulos, Efthymia Giannitsioti, Frantzeska Frantzeskaki, Iraklis Tsangaris, Spyros Pournaras, Joseph Meletiadis^*

^*Corresponding author for this work

Department of Clinical Microbiology

28 Citations (Scopus)

Abstract

The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1−2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1.

Original language	English
Article number	931
Journal	Journal of fungi (Basel, Switzerland)
Volume	8
Issue number	9
Pages (from-to)	1-7
Number of pages	7
ISSN	2309-608X
DOIs	https://doi.org/10.3390/jof8090931
Publication status	Published - 1 Sept 2022

Keywords

Candida parapsilosis
FKS1 mutation
acquired resistance
echinocandin

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10.3390/jof8090931

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Siopi, M., Papadopoulos, A., Spiliopoulou, A., Paliogianni, F., Abou-Chakra, N., Arendrup, M. C., Damoulari, C., Tsioulos, G., Giannitsioti, E., Frantzeskaki, F., Tsangaris, I., Pournaras, S., & Meletiadis, J. (2022). Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy. Journal of fungi (Basel, Switzerland), 8(9), 1-7. Article 931. https://doi.org/10.3390/jof8090931

Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy. / Siopi, Maria; Papadopoulos, Antonios; Spiliopoulou, Anastasia et al.
In: Journal of fungi (Basel, Switzerland), Vol. 8, No. 9, 931, 01.09.2022, p. 1-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Siopi, M, Papadopoulos, A, Spiliopoulou, A, Paliogianni, F, Abou-Chakra, N, Arendrup, MC, Damoulari, C, Tsioulos, G, Giannitsioti, E, Frantzeskaki, F, Tsangaris, I, Pournaras, S & Meletiadis, J 2022, 'Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy', Journal of fungi (Basel, Switzerland), vol. 8, no. 9, 931, pp. 1-7. https://doi.org/10.3390/jof8090931

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abstract = "The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1−2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1.",

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AU - Papadopoulos, Antonios

AU - Spiliopoulou, Anastasia

AU - Paliogianni, Fotini

AU - Abou-Chakra, Nissrine

AU - Arendrup, Maiken Cavling

AU - Damoulari, Christina

AU - Tsioulos, Georgios

AU - Giannitsioti, Efthymia

AU - Frantzeskaki, Frantzeska

AU - Tsangaris, Iraklis

AU - Pournaras, Spyros

AU - Meletiadis, Joseph

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N2 - The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1−2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1.

AB - The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1−2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1.

KW - Candida parapsilosis

KW - FKS1 mutation

KW - acquired resistance

KW - echinocandin

UR - https://www.scopus.com/pages/publications/85138616692

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DO - 10.3390/jof8090931

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JO - Journal of fungi (Basel, Switzerland)

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ER -

Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy

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Keywords

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