TY - JOUR
T1 - P-wave duration and the risk of atrial fibrillation
T2 - Results from the Copenhagen ECG Study
AU - Nielsen, Jonas B
AU - Kühl, Jørgen T
AU - Pietersen, Adrian
AU - Graff, Claus
AU - Lind, Bent
AU - Struijk, Johannes J
AU - Olesen, Morten S
AU - Sinner, Moritz F
AU - Bachmann, Troels Nørgaard
AU - Haunsø, Stig
AU - Nordestgaard, Børge G
AU - Ellinor, Patrick T
AU - Svendsen, Jesper H
AU - Kofoed, Klaus F
AU - Køber, Lars
AU - Holst, Anders G
N1 - Copyright © 2015 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
PY - 2015/9
Y1 - 2015/9
N2 - BACKGROUND: Results on the association between P-wave duration and the risk of atrial fibrillation (AF) are conflicting.OBJECTIVE: The purpose of this study was to obtain a detailed description of the relationship between P-wave duration and the risk of AF.METHODS: Using computerized analysis of electrocardiograms from a large primary care population, we evaluated the association between P-wave duration and the risk of AF. Secondary end-points were death from cardiovascular causes and putative ischemic stroke. Data on drug use, comorbidity, and outcomes were collected from administrative registries.RESULTS: A total of 285,933 individuals were included. During median follow-up period of 6.7 years, 9550 developed AF, 9371 died of a cardiovascular cause, and 8980 had a stroke. Compared with the reference group (100-105 ms), individuals with very short (≤89 ms; hazard ratio [HR] 1.60, 95% confidence interval [CI] 1.41-1.81), intermediate (112-119 ms; HR 1.22, 95% CI 1.13-1.31), long (120-129 ms; HR 1.50, 95% CI 1.39-1.62), and very long P-wave duration (≥130 ms; HR 2.06, 95% CI 1.89-2.23) had an increased risk of incident AF. With respect to death from cardiovascular causes, we found an increased risk for very short (≤89 ms; HR 1.20, 95% CI 1.06-1.34), long (120-129 ms; HR 1.11, 95% CI 1.04-1.19), and very long P-wave duration (≥130 ms; HR 1.30, 95% CI 1.21-1.40) compared with the reference group (106-111 ms). Similar but weaker associations were found between P-wave duration and the risk of putative ischemic stroke.CONCLUSION: In a large primary care population we found both short and long P-wave duration to be robustly associated with an increased risk of AF.
AB - BACKGROUND: Results on the association between P-wave duration and the risk of atrial fibrillation (AF) are conflicting.OBJECTIVE: The purpose of this study was to obtain a detailed description of the relationship between P-wave duration and the risk of AF.METHODS: Using computerized analysis of electrocardiograms from a large primary care population, we evaluated the association between P-wave duration and the risk of AF. Secondary end-points were death from cardiovascular causes and putative ischemic stroke. Data on drug use, comorbidity, and outcomes were collected from administrative registries.RESULTS: A total of 285,933 individuals were included. During median follow-up period of 6.7 years, 9550 developed AF, 9371 died of a cardiovascular cause, and 8980 had a stroke. Compared with the reference group (100-105 ms), individuals with very short (≤89 ms; hazard ratio [HR] 1.60, 95% confidence interval [CI] 1.41-1.81), intermediate (112-119 ms; HR 1.22, 95% CI 1.13-1.31), long (120-129 ms; HR 1.50, 95% CI 1.39-1.62), and very long P-wave duration (≥130 ms; HR 2.06, 95% CI 1.89-2.23) had an increased risk of incident AF. With respect to death from cardiovascular causes, we found an increased risk for very short (≤89 ms; HR 1.20, 95% CI 1.06-1.34), long (120-129 ms; HR 1.11, 95% CI 1.04-1.19), and very long P-wave duration (≥130 ms; HR 1.30, 95% CI 1.21-1.40) compared with the reference group (106-111 ms). Similar but weaker associations were found between P-wave duration and the risk of putative ischemic stroke.CONCLUSION: In a large primary care population we found both short and long P-wave duration to be robustly associated with an increased risk of AF.
U2 - 10.1016/j.hrthm.2015.04.026
DO - 10.1016/j.hrthm.2015.04.026
M3 - Journal article
C2 - 25916567
SN - 1547-5271
VL - 12
SP - 1887
EP - 1895
JO - Heart rhythm : the official journal of the Heart Rhythm Society
JF - Heart rhythm : the official journal of the Heart Rhythm Society
IS - 9
ER -