P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs

Oana Ciofu; Helle Krogh Johansen; Kasper Aanaes; Tina Wassermann; Morten Alhede; Christian von Buchwald; Niels Høiby

doi:10.1016/j.jcf.2013.02.004

P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs

Oana Ciofu, Helle Krogh Johansen, Kasper Aanaes, Tina Wassermann, Morten Alhede, Christian von Buchwald, Niels Høiby

61 Citations (Scopus)

Abstract

Pseudomonas aeruginosa cells are present as biofilms in the paranasal sinuses and the lungs of chronically infected cystic fibrosis (CF) patients. Since different inflammatory responses and selective antibiotic pressures are acting in the sinuses compared with the lungs, we compared the adaptive profiles of mucoid and non-mucoid isolates from the two locations.

Original language	English
Journal	Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Volume	12
Issue number	6
Pages (from-to)	729-36
Number of pages	8
ISSN	1569-1993
DOIs	https://doi.org/10.1016/j.jcf.2013.02.004
Publication status	Published - Dec 2013

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Ciofu, O., Johansen, H. K., Aanaes, K., Wassermann, T., Alhede, M., von Buchwald, C., & Høiby, N. (2013). P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 12(6), 729-36. https://doi.org/10.1016/j.jcf.2013.02.004

P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs. / Ciofu, Oana; Johansen, Helle Krogh ; Aanaes, Kasper et al.
In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, Vol. 12, No. 6, 12.2013, p. 729-36.

Research output: Contribution to journal › Journal article › Research › peer-review

Ciofu, O, Johansen, HK , Aanaes, K, Wassermann, T, Alhede, M, von Buchwald, C & Høiby, N 2013, 'P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs', Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, vol. 12, no. 6, pp. 729-36. https://doi.org/10.1016/j.jcf.2013.02.004

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abstract = "Pseudomonas aeruginosa cells are present as biofilms in the paranasal sinuses and the lungs of chronically infected cystic fibrosis (CF) patients. Since different inflammatory responses and selective antibiotic pressures are acting in the sinuses compared with the lungs, we compared the adaptive profiles of mucoid and non-mucoid isolates from the two locations.",

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AU - Alhede, Morten

AU - von Buchwald, Christian

AU - Høiby, Niels

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P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs

Abstract

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