Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Oxytocin and the initiation of parturition. A review

Research output: Contribution to journalReviewResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Giraldi, A ; Enevoldsen, A S ; Wagner, G. / Oxytocin and the initiation of parturition. A review. In: Danish Medical Journal. 1990 ; Vol. 37, No. 4. pp. 377-83.

Bibtex

@article{fe76dcd3f058436f9b7eb13c7a33f3b1,
title = "Oxytocin and the initiation of parturition. A review",
abstract = "Oxytocin (OT) binds to specific receptors of myometrial cells, inducing and increasing myometrial contractions. During pregnancy and especially close to term, an increase in the myometrial OT-receptor concentration is found, leading to an increased sensitivity of the myometrium towards circulating OT. The factors determining the receptor level are not completely understood, but may include the level of steroids, OT- and oestrogenreceptors. Because of the increased sensitivity, only a small increase in the maternal OT blood-level is necessary to induce myometrial contractions at term. The level of maternal plasma OT does not change significantly throughout pregnancy. The fetus is found to secrete considerable amounts of OT during the first stage of labour, which reaches the myometrium in spite of the high level of oxytocinase in placenta. At the second stage of labour the distension of the lower birth canal might cause release of OT from the maternal neurohypophysis into the blood, increasing the myometrial contractions. This mechanism is observed in animals, but not established in the human.",
keywords = "Amino Acid Sequence, Female, Fetus/metabolism, Humans, Labor, Obstetric/physiology, Molecular Sequence Data, Oxytocin/physiology, Pregnancy, Receptors, Angiotensin/biosynthesis, Receptors, Oxytocin, Uterine Contraction/physiology",
author = "A Giraldi and Enevoldsen, {A S} and G Wagner",
year = "1990",
month = aug,
language = "English",
volume = "37",
pages = "377--83",
journal = "Danish Medical Journal",
issn = "2245-1919",
publisher = "Almindelige Danske Laegeforening",
number = "4",

}

RIS

TY - JOUR

T1 - Oxytocin and the initiation of parturition. A review

AU - Giraldi, A

AU - Enevoldsen, A S

AU - Wagner, G

PY - 1990/8

Y1 - 1990/8

N2 - Oxytocin (OT) binds to specific receptors of myometrial cells, inducing and increasing myometrial contractions. During pregnancy and especially close to term, an increase in the myometrial OT-receptor concentration is found, leading to an increased sensitivity of the myometrium towards circulating OT. The factors determining the receptor level are not completely understood, but may include the level of steroids, OT- and oestrogenreceptors. Because of the increased sensitivity, only a small increase in the maternal OT blood-level is necessary to induce myometrial contractions at term. The level of maternal plasma OT does not change significantly throughout pregnancy. The fetus is found to secrete considerable amounts of OT during the first stage of labour, which reaches the myometrium in spite of the high level of oxytocinase in placenta. At the second stage of labour the distension of the lower birth canal might cause release of OT from the maternal neurohypophysis into the blood, increasing the myometrial contractions. This mechanism is observed in animals, but not established in the human.

AB - Oxytocin (OT) binds to specific receptors of myometrial cells, inducing and increasing myometrial contractions. During pregnancy and especially close to term, an increase in the myometrial OT-receptor concentration is found, leading to an increased sensitivity of the myometrium towards circulating OT. The factors determining the receptor level are not completely understood, but may include the level of steroids, OT- and oestrogenreceptors. Because of the increased sensitivity, only a small increase in the maternal OT blood-level is necessary to induce myometrial contractions at term. The level of maternal plasma OT does not change significantly throughout pregnancy. The fetus is found to secrete considerable amounts of OT during the first stage of labour, which reaches the myometrium in spite of the high level of oxytocinase in placenta. At the second stage of labour the distension of the lower birth canal might cause release of OT from the maternal neurohypophysis into the blood, increasing the myometrial contractions. This mechanism is observed in animals, but not established in the human.

KW - Amino Acid Sequence

KW - Female

KW - Fetus/metabolism

KW - Humans

KW - Labor, Obstetric/physiology

KW - Molecular Sequence Data

KW - Oxytocin/physiology

KW - Pregnancy

KW - Receptors, Angiotensin/biosynthesis

KW - Receptors, Oxytocin

KW - Uterine Contraction/physiology

M3 - Review

C2 - 2173995

VL - 37

SP - 377

EP - 383

JO - Danish Medical Journal

JF - Danish Medical Journal

SN - 2245-1919

IS - 4

ER -

ID: 61925974