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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Oxytocin and the initiation of parturition. A review

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  1. Injuries Related to the Use of Electric Scooters in a Danish Emergency Department - a Descriptive Study

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  2. Effect and safety of endoscopic sleeve gastroplasty for treatning obesity - a systematic review

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  3. Danish norms for the Strengths and Difficulties Questionnaire

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  4. A nationwide study of the quality of surgical guidelines and written patient information

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  5. Prevalence of sarcopenia in a Danish geriatric out-patient population

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  1. Hyperseksualitet

    Research output: Contribution to journalJournal articleCommunication

  2. Sexual Health and Dysfunction in Patients With Rheumatoid Arthritis: A Cross-sectional Single-Center Study

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Oxytocin (OT) binds to specific receptors of myometrial cells, inducing and increasing myometrial contractions. During pregnancy and especially close to term, an increase in the myometrial OT-receptor concentration is found, leading to an increased sensitivity of the myometrium towards circulating OT. The factors determining the receptor level are not completely understood, but may include the level of steroids, OT- and oestrogenreceptors. Because of the increased sensitivity, only a small increase in the maternal OT blood-level is necessary to induce myometrial contractions at term. The level of maternal plasma OT does not change significantly throughout pregnancy. The fetus is found to secrete considerable amounts of OT during the first stage of labour, which reaches the myometrium in spite of the high level of oxytocinase in placenta. At the second stage of labour the distension of the lower birth canal might cause release of OT from the maternal neurohypophysis into the blood, increasing the myometrial contractions. This mechanism is observed in animals, but not established in the human.

Original languageEnglish
JournalDanish Medical Journal
Volume37
Issue number4
Pages (from-to)377-83
Number of pages7
ISSN0907-8916
Publication statusPublished - Aug 1990

    Research areas

  • Amino Acid Sequence, Female, Fetus/metabolism, Humans, Labor, Obstetric/physiology, Molecular Sequence Data, Oxytocin/physiology, Pregnancy, Receptors, Angiotensin/biosynthesis, Receptors, Oxytocin, Uterine Contraction/physiology

ID: 61925974