TY - GEN
T1 - Overnight control of blood glucose in people with type 1 diabetes
AU - Boiroux, Dimitri
AU - Duun-Henriksen, Anne Katrine
AU - Schmidt, Signe
AU - Nørgaard, Kirsten
AU - Madsbad, Sten
AU - Skyggebjerg, Ole
AU - Jensen, Peter Ruhdal
AU - Poulsen, Niels Kjølstad
AU - Madsen, Henrik
AU - Jørgensen, John Bagterp
PY - 2012/1/1
Y1 - 2012/1/1
N2 - In this paper, we develop and test a Model Predictive Controller (MPC) for overnight stabilization of blood glucose in people with type 1 diabetes. The controller uses glucose measurements from a continuous glucose monitor (CGM) and its decisions are implemented by a continuous subcutaneous insulin infusion (CSII) pump. Based on a priori patient information, we propose a systematic method for computation of the model parameters in the MPC. Safety layers improve the controller robustness and reduce the risk of hypoglycemia. The controller is evaluated in silico on a cohort of 100 randomly generated patients with a representative intersubject variability. This cohort is simulated overnight with realistic variations in the insulin sensitivities and needs. Finally, we provide results for the first tests of this controller in a real clinic.
AB - In this paper, we develop and test a Model Predictive Controller (MPC) for overnight stabilization of blood glucose in people with type 1 diabetes. The controller uses glucose measurements from a continuous glucose monitor (CGM) and its decisions are implemented by a continuous subcutaneous insulin infusion (CSII) pump. Based on a priori patient information, we propose a systematic method for computation of the model parameters in the MPC. Safety layers improve the controller robustness and reduce the risk of hypoglycemia. The controller is evaluated in silico on a cohort of 100 randomly generated patients with a representative intersubject variability. This cohort is simulated overnight with realistic variations in the insulin sensitivities and needs. Finally, we provide results for the first tests of this controller in a real clinic.
UR - http://www.scopus.com/inward/record.url?scp=84881068340&partnerID=8YFLogxK
U2 - 10.3182/20120829-3-HU-2029.00106
DO - 10.3182/20120829-3-HU-2029.00106
M3 - Article in proceedings
AN - SCOPUS:84881068340
SN - 9783902823106
T3 - IFAC Proceedings Volumes (IFAC-PapersOnline)
SP - 73
EP - 78
BT - Proceedings of the 8th IFAC Symposium on Biological and Medical Systems, BMS 2012
PB - IFAC Secretariat
T2 - 8th IFAC Symposium on Biological and Medical Systems, BMS 2012
Y2 - 29 August 2012 through 31 August 2012
ER -