Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Ovarian reserve markers after discontinuing long-term use of combined oral contraceptives

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Empathetic application of machine learning may address appropriate utilization of ART

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Futures and fears in the freezer: Danish women's experiences with ovarian tissue cryopreservation and transplantation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The reproductive microbiome - clinical practice recommendations for fertility specialists

    Research output: Contribution to journalReviewpeer-review

  4. The effect of intra-ovarian androgen priming on ovarian reserve parameters in Bologna poor responders

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Chance of live birth: a nationwide, registry-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Serum ferritin level is inversely related to number of previous pregnancy losses in women with recurrent pregnancy loss

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies at Delivery in Women, Partners, and Newborns

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Pregnancy outcomes following oocyte donation

    Research output: Contribution to journalReviewpeer-review

View graph of relations

RESEARCH QUESTION: How early do the ovarian reserve markers anti-Müllerian hormone (AMH) and antral follicle count (AFC) normalize after discontinuation of the long-term use of combined oral contraceptives (COC).

DESIGN: This was a prospective cohort study of 68 women with a history of long-term COC use. Serum AMH concentrations, ovarian volume and AFC were measured during COC use and serially in a 4-month period after discontinuing COC: 1 and 2 weeks after discontinuation, and on cycle day 2-5 during three consecutive menstrual cycles. Changes in AMH and AFC were investigated using linear mixed models of repeated measurements adjusted for relevant covariates.

RESULTS: Mean age was 29.4 years and mean duration of COC use 8.0 years. Baseline median AMH concentrations during COC use of 13 pmol/l (interquartile range [IQR] 8.4-22 pmol/l) increased to a median of 22.5 pmol/l (IQR 11-37 mol/l) 3 months after discontinuation. The estimated average increase was 53% (95% confidence interval [CI] 1.40-1.68, P < 0.001). AFC increased from a median value of 17 (IQR 11-25) to 24 (IQR 17-34). The estimated average increase was 41% (95% CI 1.30-1.52, P < 0.001). Ovarian volume increased from 2.4 to 5.8 ml (P < 0.001). The ovarian reserve markers increased continuously from baseline measurements until 2 months after discontinuation. Thereafter a plateau was reached.

CONCLUSION: After discontinuation of COC, AMH increased by 53% and AFC by 41%, with values returning to normal within 2 months. This study provides clinicians with the highly relevant knowledge that AMH and AFC can be measured 2 months after discontinuation of COC without having to account for their influence.

Original languageEnglish
JournalReproductive BioMedicine Online
Volume40
Issue number1
Pages (from-to)176-186
Number of pages11
ISSN1472-6483
DOIs
Publication statusPublished - Jan 2020

ID: 62291965