Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Outpatient photodynamic-guided diagnosis of carcinoma in situ with flexible cystoscopy: an alternative to conventional inpatient photodynamic-guided bladder biopsies in the operating theatre?

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Development and validation of a simulator-based test in transurethral resection of bladder tumours (TURBEST)

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Educational level and first-time PSA testing in general practice

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Successful extraction of sperm cells after autologous bone marrow transplant: a case report

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The prognostic impact of incidental prostate cancer following radical cystoprostatectomy: a nationwide analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Predictive value of AZGP1 following radical prostatectomy for prostate cancer: a cohort study and meta-analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Prognostic factors for relapse in patients with clinical stage I testicular cancer: Protocol for a Danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 5hmC Level Predicts Biochemical Failure Following Radical Prostatectomy in Prostate Cancer Patients with ERG Negative Tumors

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Meta-analysis of penile cancer: conceptual interpretations - Authors' reply

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The prognostic impact of incidental prostate cancer following radical cystoprostatectomy: a nationwide analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVE: The aim of this prospective open comparative study was to establish whether conventional photodynamic-guided bladder biopsies using general anaesthesia and rigid resectoscopes (inpatient) can be replaced with less traumatic flexible cystoscopy in non-sedated patients (outpatient), without compromising the diagnosis of carcinoma in situ (CIS).

MATERIALS AND METHODS: Thirty-one patients were included. After BCG instillation for CIS, bladder biopsies were obtained using photodynamic-guided flexible cystoscopy. Two weeks later, patients underwent the conventional inpatient procedure. An external pathologist reviewed the biopsy samples. Pain and quality of life (QoL) symptom score were recorded.

RESULTS: Post-BCG biopsies showed only CIS in 10 patients; high-grade Ta or T1 tumour in three patients, who were referred for cystectomy; and normal or low-grade tumour tissue in 18 patients. There was a high agreement of identification of high-grade disease in biopsies and cytology using the two methods (κ = 0.93, 95% confidence interval 0.8-1.0). The outpatient procedure identified four high-grade patients diagnosed as 'normal/low-grade' in the inpatient procedure. The opposite was observed in two patients. Quality of biopsies did not differ between the two procedures. Pain scores for outpatients were low, and median QoL symptom score was significantly lower than for inpatients (24 vs 33, p = 0.02). Hospital length of stay was significantly longer for inpatients.

CONCLUSIONS: Outpatient photodynamic-guided flexible cystoscopy is less traumatic than the conventional inpatient procedure in the diagnosis of CIS. It is safe and cost-effective, and may be an alternative to conventional inpatient biopsy procedures in patients with malignant urine cytology and normal white-light cystoscopy.

Original languageEnglish
JournalScandinavian Journal of Urology
Volume51
Issue number5
Pages (from-to)376-380
Number of pages5
ISSN2168-1805
DOIs
Publication statusPublished - Oct 2017

    Research areas

  • Journal Article

ID: 51974864