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Outcomes of monoamniotic twin pregnancies managed primarily in outpatient care-A Danish multicenter study

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@article{22dd90c42e8741989a3d3eccd93bef22,
title = "Outcomes of monoamniotic twin pregnancies managed primarily in outpatient care-A Danish multicenter study",
abstract = "INTRODUCTION: Monoamniotic twin pregnancies are high-risk pregnancies, and management by inpatient or frequent outpatient care is recommended. We report the outcomes of a national cohort of monoamniotic twin pregnancies managed primarily as outpatients MATERIAL AND METHODS: We analyzed prospectively recorded data from the Danish Fetal Medicine Database, local databases, and medical records of all monoamniotic twin pregnancies diagnosed at the first trimester scan or later, and managed at the six major fetal medicine centers in Denmark over a 10 year period RESULTS: Sixty-one monoamniotic twin pregnancies were included. Thirteen pregnancies were terminated early. Of the remaining 48 pregnancies with a normal first trimester scan, there were 36 fetal losses (25 spontaneous miscarriages <22+0 weeks, three late terminations and eight intrauterine deaths >22 weeks) and 60 live-born children (62.5{\%}), all of whom were delivered by cesarean delivery at a median gestational age of 33+0 weeks. Three children had minor malformations and there was one pregnancy with twin-to-twin-transfusion-syndrome. After 26+0 weeks, 78.8{\%} were managed as outpatients. Intrauterine death occurred in 3.8{\%} of outpatients and in 28.6{\%} of inpatients (admitted due to complications). At weeks 32, 33, and 34, the prospective risk of intrauterine death was 6.9{\%}, 4.2{\%}, and 5.9{\%}, respectively CONCLUSION: In this nationwide, unselected population, only 62.5{\%} of fetuses with a normal first trimester scan were born alive. In contrast, the mortality was 3.8{\%} after 26 weeks among the 78.8{\%} of the cohort that was managed as outpatients. More knowledge is still needed to predict which pregnancies are at the highest risk of intrauterine death. This article is protected by copyright. All rights reserved.",
keywords = "fetal mortality, gestational age, intrauterine fetal death, monoamniotic twin pregnancy, monozygotic, pregnancy, prenatal care, twin-to-twin transfusion syndrome, twins, ultrasonography",
author = "Caroline Madsen and Kirsten S{\o}gaard and Helle Zingenberg and J{\o}rgensen, {Finn Stener} and Hanne Rosbach and Eva Hoseth and Pedersen, {Lars Henning} and Petersen, {Olav Bj{\o}rn}",
note = "{\circledC} 2018 Nordic Federation of Societies of Obstetrics and Gynecology.",
year = "2019",
month = "4",
doi = "10.1111/aogs.13509",
language = "English",
volume = "98",
pages = "479--486",
journal = "Acta Obstetricia et Gynecologica Scandinavica",
issn = "0001-6349",
publisher = "Informa Healthcare",
number = "4",

}

RIS

TY - JOUR

T1 - Outcomes of monoamniotic twin pregnancies managed primarily in outpatient care-A Danish multicenter study

AU - Madsen, Caroline

AU - Søgaard, Kirsten

AU - Zingenberg, Helle

AU - Jørgensen, Finn Stener

AU - Rosbach, Hanne

AU - Hoseth, Eva

AU - Pedersen, Lars Henning

AU - Petersen, Olav Bjørn

N1 - © 2018 Nordic Federation of Societies of Obstetrics and Gynecology.

PY - 2019/4

Y1 - 2019/4

N2 - INTRODUCTION: Monoamniotic twin pregnancies are high-risk pregnancies, and management by inpatient or frequent outpatient care is recommended. We report the outcomes of a national cohort of monoamniotic twin pregnancies managed primarily as outpatients MATERIAL AND METHODS: We analyzed prospectively recorded data from the Danish Fetal Medicine Database, local databases, and medical records of all monoamniotic twin pregnancies diagnosed at the first trimester scan or later, and managed at the six major fetal medicine centers in Denmark over a 10 year period RESULTS: Sixty-one monoamniotic twin pregnancies were included. Thirteen pregnancies were terminated early. Of the remaining 48 pregnancies with a normal first trimester scan, there were 36 fetal losses (25 spontaneous miscarriages <22+0 weeks, three late terminations and eight intrauterine deaths >22 weeks) and 60 live-born children (62.5%), all of whom were delivered by cesarean delivery at a median gestational age of 33+0 weeks. Three children had minor malformations and there was one pregnancy with twin-to-twin-transfusion-syndrome. After 26+0 weeks, 78.8% were managed as outpatients. Intrauterine death occurred in 3.8% of outpatients and in 28.6% of inpatients (admitted due to complications). At weeks 32, 33, and 34, the prospective risk of intrauterine death was 6.9%, 4.2%, and 5.9%, respectively CONCLUSION: In this nationwide, unselected population, only 62.5% of fetuses with a normal first trimester scan were born alive. In contrast, the mortality was 3.8% after 26 weeks among the 78.8% of the cohort that was managed as outpatients. More knowledge is still needed to predict which pregnancies are at the highest risk of intrauterine death. This article is protected by copyright. All rights reserved.

AB - INTRODUCTION: Monoamniotic twin pregnancies are high-risk pregnancies, and management by inpatient or frequent outpatient care is recommended. We report the outcomes of a national cohort of monoamniotic twin pregnancies managed primarily as outpatients MATERIAL AND METHODS: We analyzed prospectively recorded data from the Danish Fetal Medicine Database, local databases, and medical records of all monoamniotic twin pregnancies diagnosed at the first trimester scan or later, and managed at the six major fetal medicine centers in Denmark over a 10 year period RESULTS: Sixty-one monoamniotic twin pregnancies were included. Thirteen pregnancies were terminated early. Of the remaining 48 pregnancies with a normal first trimester scan, there were 36 fetal losses (25 spontaneous miscarriages <22+0 weeks, three late terminations and eight intrauterine deaths >22 weeks) and 60 live-born children (62.5%), all of whom were delivered by cesarean delivery at a median gestational age of 33+0 weeks. Three children had minor malformations and there was one pregnancy with twin-to-twin-transfusion-syndrome. After 26+0 weeks, 78.8% were managed as outpatients. Intrauterine death occurred in 3.8% of outpatients and in 28.6% of inpatients (admitted due to complications). At weeks 32, 33, and 34, the prospective risk of intrauterine death was 6.9%, 4.2%, and 5.9%, respectively CONCLUSION: In this nationwide, unselected population, only 62.5% of fetuses with a normal first trimester scan were born alive. In contrast, the mortality was 3.8% after 26 weeks among the 78.8% of the cohort that was managed as outpatients. More knowledge is still needed to predict which pregnancies are at the highest risk of intrauterine death. This article is protected by copyright. All rights reserved.

KW - fetal mortality

KW - gestational age

KW - intrauterine fetal death

KW - monoamniotic twin pregnancy

KW - monozygotic

KW - pregnancy

KW - prenatal care

KW - twin-to-twin transfusion syndrome

KW - twins

KW - ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=85058694857&partnerID=8YFLogxK

U2 - 10.1111/aogs.13509

DO - 10.1111/aogs.13509

M3 - Journal article

VL - 98

SP - 479

EP - 486

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

SN - 0001-6349

IS - 4

ER -

ID: 55722043