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Outcomes Following Pouch Formation in Paediatric Ulcerative Colitis: A Study from the Porto Group of ESPGHAN

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Harvard

Orlanski-Meyer, E, Topf-Olivestone, C, Ledder, O, Dotan, I, Folmer-Hansen, L, Kindermann, A, Assa, A, Kolho, K-L, Kolaček, S, Carroll, MW, Strisciuglio, C, Aloi, M, Hansen, R, Navon, D, Winter, HS, Navas-López, VM, de Ridder, L, Smets, F, Weiss, B & Turner, D 2020, 'Outcomes Following Pouch Formation in Paediatric Ulcerative Colitis: A Study from the Porto Group of ESPGHAN', Journal of Pediatric Gastroenterology and Nutrition, vol. 71, no. 3, pp. 346-353. https://doi.org/10.1097/MPG.0000000000002805

APA

Orlanski-Meyer, E., Topf-Olivestone, C., Ledder, O., Dotan, I., Folmer-Hansen, L., Kindermann, A., Assa, A., Kolho, K-L., Kolaček, S., Carroll, M. W., Strisciuglio, C., Aloi, M., Hansen, R., Navon, D., Winter, H. S., Navas-López, V. M., de Ridder, L., Smets, F., Weiss, B., & Turner, D. (2020). Outcomes Following Pouch Formation in Paediatric Ulcerative Colitis: A Study from the Porto Group of ESPGHAN. Journal of Pediatric Gastroenterology and Nutrition, 71(3), 346-353. https://doi.org/10.1097/MPG.0000000000002805

CBE

Orlanski-Meyer E, Topf-Olivestone C, Ledder O, Dotan I, Folmer-Hansen L, Kindermann A, Assa A, Kolho K-L, Kolaček S, Carroll MW, Strisciuglio C, Aloi M, Hansen R, Navon D, Winter HS, Navas-López VM, de Ridder L, Smets F, Weiss B, Turner D. 2020. Outcomes Following Pouch Formation in Paediatric Ulcerative Colitis: A Study from the Porto Group of ESPGHAN. Journal of Pediatric Gastroenterology and Nutrition. 71(3):346-353. https://doi.org/10.1097/MPG.0000000000002805

MLA

Vancouver

Author

Orlanski-Meyer, Esther ; Topf-Olivestone, Chani ; Ledder, Oren ; Dotan, Iris ; Folmer-Hansen, Lars ; Kindermann, Angelika ; Assa, Amit ; Kolho, Kaija-Leena ; Kolaček, Sanja ; Carroll, Matthew W ; Strisciuglio, Caterina ; Aloi, Marina ; Hansen, Richard ; Navon, Dan ; Winter, Harland S ; Navas-López, Victor Manuel ; de Ridder, Lissy ; Smets, Françoise ; Weiss, Batia ; Turner, Dan. / Outcomes Following Pouch Formation in Paediatric Ulcerative Colitis : A Study from the Porto Group of ESPGHAN. In: Journal of Pediatric Gastroenterology and Nutrition. 2020 ; Vol. 71, No. 3. pp. 346-353.

Bibtex

@article{96a2d68271fb425fbdcffc3c7f42e2df,
title = "Outcomes Following Pouch Formation in Paediatric Ulcerative Colitis: A Study from the Porto Group of ESPGHAN",
abstract = "INTRODUCTION: Contemporary pediatric data on pouch outcomes are sparse, especially in the era of laparoscopic surgeries. We aimed to assess outcomes and predictors in children with ulcerative colitis/inflammatory bowel disease (IBD)-unclassified who underwent colectomy and ileal pouch-anal anastomosis. METHODS: This was a multicenter retrospective cohort study from 17 IBD centers affiliated with the pediatric IBD Porto group of ESPGHAN. An electronic REDcap system was used to collate baseline characteristics, demographic, clinical, management and surgical data, short- and long-term outcomes, and to identify potential predictors of pouch outcome. RESULTS: Of the 129 patients included, 86 (67%) developed pouchitis during follow-up of median 40 months (interquartile range 26-72), of whom 33 (26%) with chronic pouchitis. Patients operated on by surgeons performing <10 pouch surgeries/year had a higher rate of chronic pouchitis (11/27 [41%] vs 8/54 [15%], P = 0.013) on both univariable and multivariable analyses and also associated with time to pouchitis (P = 0.018) and chronic pouchitis (P = 0.020). At last follow-up, overall pouch performance was rated good/excellent in 86 (74%) patients. Time from colectomy to pouch formation was not associated with pouch outcomes. Despite higher rate of nonsevere surgical complications among children undergoing colectomy at <10 years of age (7/16 [44%] vs 10/92 [11%], P = 0.003), functional outcome and pouchitis rate did not differ. CONCLUSIONS: Pouchitis rate in children with ulcerative colitis/IBD unclassified is high. Surgeon experience is the major modifiable risk factor for pouch outcome. Our analyses suggest that pouch surgery can also be performed successfully in young children.",
author = "Esther Orlanski-Meyer and Chani Topf-Olivestone and Oren Ledder and Iris Dotan and Lars Folmer-Hansen and Angelika Kindermann and Amit Assa and Kaija-Leena Kolho and Sanja Kola{\v c}ek and Carroll, {Matthew W} and Caterina Strisciuglio and Marina Aloi and Richard Hansen and Dan Navon and Winter, {Harland S} and Navas-L{\'o}pez, {Victor Manuel} and {de Ridder}, Lissy and Fran{\c c}oise Smets and Batia Weiss and Dan Turner",
year = "2020",
month = sep,
day = "1",
doi = "10.1097/MPG.0000000000002805",
language = "English",
volume = "71",
pages = "346--353",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - Outcomes Following Pouch Formation in Paediatric Ulcerative Colitis

T2 - A Study from the Porto Group of ESPGHAN

AU - Orlanski-Meyer, Esther

AU - Topf-Olivestone, Chani

AU - Ledder, Oren

AU - Dotan, Iris

AU - Folmer-Hansen, Lars

AU - Kindermann, Angelika

AU - Assa, Amit

AU - Kolho, Kaija-Leena

AU - Kolaček, Sanja

AU - Carroll, Matthew W

AU - Strisciuglio, Caterina

AU - Aloi, Marina

AU - Hansen, Richard

AU - Navon, Dan

AU - Winter, Harland S

AU - Navas-López, Victor Manuel

AU - de Ridder, Lissy

AU - Smets, Françoise

AU - Weiss, Batia

AU - Turner, Dan

PY - 2020/9/1

Y1 - 2020/9/1

N2 - INTRODUCTION: Contemporary pediatric data on pouch outcomes are sparse, especially in the era of laparoscopic surgeries. We aimed to assess outcomes and predictors in children with ulcerative colitis/inflammatory bowel disease (IBD)-unclassified who underwent colectomy and ileal pouch-anal anastomosis. METHODS: This was a multicenter retrospective cohort study from 17 IBD centers affiliated with the pediatric IBD Porto group of ESPGHAN. An electronic REDcap system was used to collate baseline characteristics, demographic, clinical, management and surgical data, short- and long-term outcomes, and to identify potential predictors of pouch outcome. RESULTS: Of the 129 patients included, 86 (67%) developed pouchitis during follow-up of median 40 months (interquartile range 26-72), of whom 33 (26%) with chronic pouchitis. Patients operated on by surgeons performing <10 pouch surgeries/year had a higher rate of chronic pouchitis (11/27 [41%] vs 8/54 [15%], P = 0.013) on both univariable and multivariable analyses and also associated with time to pouchitis (P = 0.018) and chronic pouchitis (P = 0.020). At last follow-up, overall pouch performance was rated good/excellent in 86 (74%) patients. Time from colectomy to pouch formation was not associated with pouch outcomes. Despite higher rate of nonsevere surgical complications among children undergoing colectomy at <10 years of age (7/16 [44%] vs 10/92 [11%], P = 0.003), functional outcome and pouchitis rate did not differ. CONCLUSIONS: Pouchitis rate in children with ulcerative colitis/IBD unclassified is high. Surgeon experience is the major modifiable risk factor for pouch outcome. Our analyses suggest that pouch surgery can also be performed successfully in young children.

AB - INTRODUCTION: Contemporary pediatric data on pouch outcomes are sparse, especially in the era of laparoscopic surgeries. We aimed to assess outcomes and predictors in children with ulcerative colitis/inflammatory bowel disease (IBD)-unclassified who underwent colectomy and ileal pouch-anal anastomosis. METHODS: This was a multicenter retrospective cohort study from 17 IBD centers affiliated with the pediatric IBD Porto group of ESPGHAN. An electronic REDcap system was used to collate baseline characteristics, demographic, clinical, management and surgical data, short- and long-term outcomes, and to identify potential predictors of pouch outcome. RESULTS: Of the 129 patients included, 86 (67%) developed pouchitis during follow-up of median 40 months (interquartile range 26-72), of whom 33 (26%) with chronic pouchitis. Patients operated on by surgeons performing <10 pouch surgeries/year had a higher rate of chronic pouchitis (11/27 [41%] vs 8/54 [15%], P = 0.013) on both univariable and multivariable analyses and also associated with time to pouchitis (P = 0.018) and chronic pouchitis (P = 0.020). At last follow-up, overall pouch performance was rated good/excellent in 86 (74%) patients. Time from colectomy to pouch formation was not associated with pouch outcomes. Despite higher rate of nonsevere surgical complications among children undergoing colectomy at <10 years of age (7/16 [44%] vs 10/92 [11%], P = 0.003), functional outcome and pouchitis rate did not differ. CONCLUSIONS: Pouchitis rate in children with ulcerative colitis/IBD unclassified is high. Surgeon experience is the major modifiable risk factor for pouch outcome. Our analyses suggest that pouch surgery can also be performed successfully in young children.

UR - http://www.scopus.com/inward/record.url?scp=85089805418&partnerID=8YFLogxK

U2 - 10.1097/MPG.0000000000002805

DO - 10.1097/MPG.0000000000002805

M3 - Journal article

C2 - 32541197

VL - 71

SP - 346

EP - 353

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 3

ER -

ID: 60095773