Outcome of SARS-CoV-2 infection among patients with common variable immunodeficiency and a matched control group: A Danish nationwide cohort study

Terese L Katzenstein, Line D Rasmussen, Camilla Helberg Drabe, Carsten Schade Larsen, Ann-Brit Eg Hansen, Mette Stærkind, Lene Surland Knudsen, Christian Holm Hansen, Niels Obel

Abstract

The risk of severe adult respiratory coronavirus-2 (SARS-CoV-2) infection and the course of the infection among individuals with common variable immunodeficiency (CVID) relative to the general population have been a matter of debate. We conducted a Danish nationwide study comparing the timing of SARS-CoV-2 vaccination, the risk of first confirmed SARS-CoV-2 infection, re-infection, and the outcome of infection among individuals with CVID relative to an age- and gender matched control group. Cox regression was used to calculate incidence rate ratios. The CVID patients received SARS-CoV-2 vaccinations earlier than those included in the population control group. Even so, the risks of both first infection and re-infection were increased among the individuals with CVID. The CVID group also had increased risk for hospital contacts due to SARS-CoV-2 infection relative to the general population. However, reassuringly, the risk of mechanical ventilation and death did not differ between the groups, but the numbers were low in both groups, making the estimates uncertain. Though this is the largest study to investigate the risk of SARS-CoV-2 infections and outcomes hereof among individuals with CVID relative to the general population, we cannot rule out minor differences in severity, which might only be detectable with an even larger sample size.

Original languageEnglish
Article number994253
JournalFrontiers in Immunology
Volume13
Pages (from-to)994253
ISSN1664-3224
DOIs
Publication statusPublished - 2022

Keywords

  • Adult
  • COVID-19/epidemiology
  • COVID-19 Vaccines
  • Cohort Studies
  • Common Variable Immunodeficiency/complications
  • Denmark/epidemiology
  • Humans
  • Reinfection
  • SARS-CoV-2

Fingerprint

Dive into the research topics of 'Outcome of SARS-CoV-2 infection among patients with common variable immunodeficiency and a matched control group: A Danish nationwide cohort study'. Together they form a unique fingerprint.

Cite this